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Observational Study
. 2021 Oct 19;21(1):504.
doi: 10.1186/s12872-021-02316-8.

The ratio of HDL-C to apoA-I interacts with free triiodothyronine to modulate coronary artery disease risk

Li Li  1 , Gaojun Cai  2 , Wei Lu  3 , Feng Li  3 , Lei Yu  3 , Jianqiang Xiao  3
Affiliations
Observational Study

The ratio of HDL-C to apoA-I interacts with free triiodothyronine to modulate coronary artery disease risk

Li Li et al. BMC Cardiovasc Disord. .

Abstract

Objective: In the present work, research was carried out to explore the correlation between the high-density lipoprotein cholesterol (HDL-C)/apolipoprotein A-I (apoA-I) ratio and serum free triiodothyronine (FT3) and their interaction on the risk of coronary artery disease (CAD).

Methods: A total of 1686 patients who underwent selective coronary angiography were enrolled in the present study, including 1279 patients with CAD and 407 controls. The subjects were divided into three groups according to tertiles of the HDL-C/apoA-I ratio. Binary logistic regression analysis was used to evaluate the interaction of the HDL-C/apoA-I ratio and FT3 level with the risk of CAD.

Results: The group with the highest HDL-C/apoA-I ratio had the lowest levels of FT3. Multiple linear regression analysis showed that the HDL-C/apoA-I ratio was negatively associated with FT3 after adjusting for age, sex, body mass index (BMI), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), FT4 and TSH. A logistic regression model showed that a high HDL-C/apoA-I ratio (> 0.89 mmol/g) and high FT3 levels (> 4.5 pmol/l) were protective factors for CAD. Patients with a lower HDL-C/apoA-I ratio (≤ 0.89 mmol/g) and lower FT3 level (≤ 4.5 pmol/l) had an increased risk of CAD (OR = 2.441, P = 0.000, S = 1.13, AP = 0.068, AP* = 0.116, RERI = 0.168).

Conclusions: The HDL-C/apoA-I ratio was negatively associated with FT3, and there was a significant interaction between the HDL-C/apoA-I ratio and FT3 with the risk of CAD.

Keywords: Coronary artery disease; Free triiodothyronine; High-density lipoprotein cholesterol/apolipoprotein A-I.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow of study participant selection
Fig. 2
Fig. 2
Interaction of the HDL-C/apoA-I ratio and FT3 level with the risk of CAD using binary logistic regression. *Adjusted for age, sex, BMI, EH, LDL-C and TGs
Fig. 3
Fig. 3
Stratified analysis of the interaction between the HDL-C/apoA-I ratio and FT3 level by age, DM status
See this image and copyright information in PMC

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