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Review
. 2021 Oct 1;13(10):e1038-e1048.
doi: 10.4317/jced.58567. eCollection 2021 Oct.

Effects of natural extracts in the treatment of oral ulcers: A systematic review of evidence from experimental studies in animals

Schilin D Wen  1   2 , Eulàlia Sans-Serramitjana  1   3 , Javiera F Santander  1 , Mariela R Sánchez  1 , Paulina Salazar-Aguilar  1 , Andrea B Zepeda  1   4 , Susana I Alvarado  1   4 , Ignacia B Miranda  1   4
Affiliations
Review

Effects of natural extracts in the treatment of oral ulcers: A systematic review of evidence from experimental studies in animals

Schilin D Wen et al. J Clin Exp Dent. .

Abstract

Background: To evaluate the clinical and histopathological effects of natural extracts in the treatment of oral ulcers induced in animal experimental models.

Material and methods: We carried out a search in the Medline, Scopus, WoS and Embase databases from the start of the databases to December 2020, and also made a manual search of the references. The search and selection were carried out by two researchers independently. The inclusion criteria were: experimental studies in animal models, in english, which complied with the study object.

Results: A total of 705 articles were identified. After selection by title, abstract and full text, 19 articles were finally included. Natural extracts of Jasminum grandiflorum, Ficus deltoidea, curcumin and Bixina orellana provoked a significantly greater reduction in the size of the ulcer. Extracts of Salvatora persica, Musa acuminate, Ganoderma lucidum mycelia and Bixina Orellana, as well as preparations of Kouyanqing Granule and curcumin, were able to reduce levels of pro-inflammatory cytokines and increase the expression and serum levels of growth factors and anti-inflammatory cytokines. Extracts of Piper sarmentosus, Cannabis sativa and Bletilla striata provoked a reduction in the severity of the histological inflammation. No significant differences were observed compared to controls in the treatments with extracts of Cannabis sativa, Aloe barbadensus Miller and Malva sylvestris in reducing the area of the oral ulcers.

Conclusions: Most of the natural extracts described in this review presented a positive clinical and histological effect on the cicatrisation of oral ulcers induced in animal models. Key words:Recurrent aphthous stomatitis, oral ulcer, plants, herbs, extracts, medicine, treatment.

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Conflict of interest statement

Conflicts of interest The authors of this review declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA Flow Diagram.
Figure 2
Figure 2
The results of the risk of bias evaluation.
Figure 3
Figure 3
The results of the risk of bias evaluation.
See this image and copyright information in PMC

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