Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Oct;36(5):1241-1244.
doi: 10.1007/s12250-021-00448-x. Epub 2021 Oct 20.

Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population

Raimonds Rescenko  1 , Raitis Peculis  1 , Monta Briviba  1 , Laura Ansone  1 , Anna Terentjeva  2 , Helena Daiga Litvina  1 , Liga Birzniece  1 , Kaspars Megnis  1 , Oksana Kolesova  2 , Baiba Rozentale  2 , Ludmila Viksna  2 , Vita Rovite  1 , Janis Klovins  3
Affiliations
Comment

Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population

Raimonds Rescenko et al. Virol Sin. 2021 Oct.

Erratum in

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Manhattan plot of 1 Mb region at 3p21.31 locus. rs11385942 variant is emphasized with a diamond shape and set as a reference for LD estimation with other SNPs in the region. Rs codes for three SNPs selected for replication are depicted in dark blue, while rs codes for other SNPs displaying lower P-value in our association study are in light blue. The dotted line represents the common genome-wide significance threshold. LD, linkage disequilibrium; SNP, single nucleotide polymorphism.
See this image and copyright information in PMC

Comment on

  • Genetic mechanisms of critical illness in COVID-19.
    Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH, Russell CD, Furniss J, Richmond A, Gountouna E, Wrobel N, Harrison D, Wang B, Wu Y, Meynert A, Griffiths F, Oosthuyzen W, Kousathanas A, Moutsianas L, Yang Z, Zhai R, Zheng C, Grimes G, Beale R, Millar J, Shih B, Keating S, Zechner M, Haley C, Porteous DJ, Hayward C, Yang J, Knight J, Summers C, Shankar-Hari M, Klenerman P, Turtle L, Ho A, Moore SC, Hinds C, Horby P, Nichol A, Maslove D, Ling L, McAuley D, Montgomery H, Walsh T, Pereira AC, Renieri A; GenOMICC Investigators; ISARIC4C Investigators; COVID-19 Human Genetics Initiative; 23andMe Investigators; BRACOVID Investigators; Gen-COVID Investigators; Shen X, Ponting CP, Fawkes A, Tenesa A, Caulfield M, Scott R, Rowan K, Murphy L, Openshaw PJM, Semple MG, Law A, Vitart V, Wilson JF, Baillie JK. Pairo-Castineira E, et al. Nature. 2021 Mar;591(7848):92-98. doi: 10.1038/s41586-020-03065-y. Epub 2020 Dec 11. Nature. 2021. PMID: 33307546

References

    1. Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ. Second-generation PLINK: rising to the challenge of larger and richer datasets. GigaScience. 2015;4:7. doi: 10.1186/s13742-015-0047-8. - DOI - PMC - PubMed
    1. COVID-19 Host Genetics Initiative (2021) Mapping the human genetic architecture of COVID-19. Nature. 10.1038/s41586-021-03767-x. - PMC - PubMed
    1. Genome Wide Association Study (GWAS) catalog (2021). Available: https://www.ebi.ac.uk/gwas/efotraits/MONDO_0100096. Accessed 26 March 2021
    1. GTEx Consortium Genetic effects on gene expression across human tissues. Nature. 2017;550:204–213. doi: 10.1038/nature24277. - DOI - PMC - PubMed
    1. Hu J, Li C, Wang S, Li T, Zhang H. Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data. Hum Genomics. 2021;15:10. doi: 10.1186/s40246-021-00306-7. - DOI - PMC - PubMed

Substances