Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Dec;72(12):1039-1047.
doi: 10.1007/s00105-021-04900-7. Epub 2021 Oct 20.

[Confocal line-field OCT]

[Article in German]
Sandra Schuh  1 , C Ruini  2 , E Sattler  2 , J Welzel  3
Affiliations
Review

[Confocal line-field OCT]

[Article in German]
Sandra Schuh et al. Hautarzt. 2021 Dec.

Abstract
in English, German

Optical coherence tomography (OCT) and confocal laser microscopy (CLSM) are established non-invasive methods in clinical dermatological routine diagnosis. Whereas CLSM is especially useful to distinguish between nevi and melanoma, OCT is suitable for the diagnosis and differentiation of non-melanoma skin cancer. Line-field confocal optical coherence tomography (LC-OCT) is a new innovative device, which has better cellular resolution than OCT and a higher penetration depth than CLSM. Similar to CLSM, LC-OCT also allows 3D images in real time to be taken. Therefore LC-OCT is very useful for the examination of skin lesions of all kinds, since it unites the features of CLSM and OCT.

Die optische Kohärenztomographie (OCT) und die konfokale Lasermikroskopie (KLM) sind in der klinischen dermatologischen Routinediagnostik bereits etablierte nichtinvasive Methoden. Während die KLM insbesondere hilfreich bei der Unterscheidung von Naevi und Melanomen ist, eignet sich die OCT vor allem zur Diagnostik und Differenzierung von nichtmelanozytärem Hautkrebs. Die LC-OCT („line-field confocal optical coherence tomography“) hingegen ist ein neues innovatives Verfahren, das über eine bessere zelluläre Auflösung als die OCT und höhere Eindringtiefe als die KLM verfügt. Mit der LC-OCT sind im Vergleich zur KLM auch 3‑D-Aufnahmen in Echtzeit möglich. Sie eignet sich sehr gut zur Untersuchung von Hautläsionen aller Art, da sie die Vorteile von KLM und OCT vereint.

Keywords: Actinic keratosis; Confocal laser microscopy; Hyperkeratosis; Melanoma; Parakeratosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

Literatur

    1. Welzel J, Schuh S (2017) Nichtinvasive Diagnostik in der Dermatologie. J Dtsch Dermatol Ges 15:999–1017 - PubMed
    1. Holmes J, von Braunmühl T, Berking C et al (2018) Optical coherence tomography of basal cell carcinoma: influence of location, subtype, observer variability and image quality on diagnostic performance. Br J Dermatol 178:1102–1110 - DOI
    1. Ulrich M, Maier T, Kurzen H et al (2015) The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of non-pigmented basal cell carcinoma—an observational study. Br J Dermatol 173:428–435 - DOI
    1. Dinnes J, Deeks JJ, Chuchu N et al (2018) Reflectance confocal microscopy for diagnosing keratinocyte skin cancers in adults. Cochrane Database Syst Rev 12:CD13191. https://doi.org/10.1002/14651858.CD013191 - DOI - PubMed
    1. Que SK, Grant-Kels JM, Longo C, Pellacani G (2016) Basics of confocal microscopy and the complexity of diagnosing skin tumors: new imaging tools in clinical practice, diagnostic workflows, cost-estimate, and new trends. Dermatol Clin 34:367–375 - DOI

LinkOut - more resources