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Randomized Controlled Trial
. 2022 Mar;30(3):2101-2110.
doi: 10.1007/s00520-021-06559-1. Epub 2021 Oct 20.

Effect of exercise mode on physical function and quality of life in breast cancer-related lymphedema: a randomized trial

Maged A Basha  1   2 , Nancy H Aboelnour  3 , Ashwag S Alsharidah  4 , FatmaAlzahraa H Kamel  5   3
Affiliations
Randomized Controlled Trial

Effect of exercise mode on physical function and quality of life in breast cancer-related lymphedema: a randomized trial

Maged A Basha et al. Support Care Cancer. 2022 Mar.

Abstract

Purpose: This study aimed to compare the effects of virtual reality (VR) training and resistance exercises training on lymphedema symptom severity as well as physical functioning and QoL in women with breast cancer-related lymphedema (BCRL).

Methods: In a single blinded randomized trial, women diagnosed with unilateral BCRL were randomly divided into two groups: the Xbox Kinect group received VR Kinect-based games (n = 30) and resistance exercise group received resistance training (n = 30). In addition, both groups received complex decongestive physiotherapy (manual lymphatic drainage, compression bandages, skin care, and exercises). The intervention was conducted five sessions per week for 8 weeks. The outcome measures included excessive limb volume, visual analogue scale (VAS), the Disability of the Arm, Shoulder, and Hand (DASH) questionnaire, shoulder range of motion (ROM), shoulder muscles strength, hand grip strength, and Study Short-Form (SF-36). The outcomes were evaluated pre and post intervention (week 8).

Results: Statistical significant differences were recorded in VAS (pain intensity), DASH, shoulder ROM (p < 0.001), bodily pain (p = 0.002), general health (p < 0.001), and vitality (p = 0.006) in favor of the Xbox Kinect group. However, there were statistically significant differences in shoulder flexion strength (p = 0.002), external rotation strength (p = 0.004), and abduction strength and handgrip strength (p < 0.001) in favor of the resistance exercise group.

Conclusions: The VR training was superior to resistance exercises training in BCRL management. The empirical findings support the VR as a new effective and encouraging intervention modality which can assist in improving physical functioning and quality of life in women with BCRL.

Trial registration: This study is retrospectively registered at ClinicalTrials.gov (ID: NCT04724356).

Keywords: Breast cancer–related lymphedema; Physical function; Quality of life; Resistance exercise; Virtual reality.

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References

    1. Vicini F, Shah C, Arthur D (2016) The increasing role of lymphedema screening, diagnosis and management as part of evidence-based guidelines for breast cancer care. Breast J 22(3):358–359. https://doi.org/10.1111/tbj.12586 - DOI - PubMed
    1. Hayes S, Rye S, Battistutta D, Newman B (2010) Prevalence of upper-body symptoms following breast cancer and its relationship with upper-body function and lymphedema. Lymphology 43(4):178–187 - PubMed
    1. Morgan PA, Franks PJ, Moffatt CJ (2005) Health-related quality of life with lymphoedema: a review of the literature. Int Wound J 2(1):47–62. https://doi.org/10.1111/j.1742-4801.2005.00066.x - DOI - PubMed - PMC
    1. Fu MR, Ridner SH, Hu SH, Stewart BR, Cormier JN, Armer JM (2013) Psychosocial impact of lymphedema: a systematic review of literature from 2004 to 2011. Psychooncology 22(7):1466–1484. https://doi.org/10.1002/pon.3201 - DOI - PubMed
    1. McWayne J, Heiney SP (2005) Psychologic and social sequelae of secondary lymphedema: a review. Cancer 104(3):457–66. https://doi.org/10.1002/cncr.21195 - DOI - PubMed

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