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Review
. 2022 Mar;28(3):483-492.
doi: 10.1002/lt.26339. Epub 2021 Nov 10.

Malnutrition in Biliary Atresia: Assessment, Management, and Outcomes

Julia M Boster  1 , Amy G Feldman, Cara L Mack, Ronald J Sokol, Shikha S Sundaram
Affiliations
Review

Malnutrition in Biliary Atresia: Assessment, Management, and Outcomes

Julia M Boster et al. Liver Transpl. 2022 Mar.

Abstract

Children with biliary atresia (BA), particularly infants, are at high risk for malnutrition attributed to a multitude of factors, including poor oral intake and intolerance of enteral feeding, fat malabsorption, abnormal nutrient metabolism, and increased caloric demand. Malnutrition and sarcopenia negatively impact outcomes in BA, leading to higher pretransplant and posttransplant morbidity and mortality. This review summarizes factors contributing to nutritional deficiencies in BA and offers an organized approach to the assessment and management of malnutrition in this vulnerable population.

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Conflict of interest statement

Conflict of Interest: The authors have indicated they have no potential conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Pathophysiology of Malnutrition in Biliary Atresia
Figure 2.
Figure 2.
Management of Malnutrition in Biliary Atresia and Effects on Transplant-Associated Outcomes
See this image and copyright information in PMC

References

    1. Sokol RJ, Shepherd RW, Superina R, Bezerra JA, Robuck P, Hoofnagle JH. Screening and outcomes in biliary atresia: summary of a National Institutes of Health workshop. Hepatology 2007;46:566–81. - PMC - PubMed
    1. Mouzaki M, Bronsky J, Gupte G, et al. Nutritional Support of Children With Chronic Liver Diseases: A Joint Position Paper of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2019;69:498–511. - PubMed
    1. Utterson EC, Shepherd RW, Sokol RJ, et al. Biliary atresia: clinical profiles, risk factors, and outcomes of 755 patients listed for liver transplantation. J Pediatr 2005;147(2):180–5. - PubMed
    1. Boster JM, Browne LP, Pan Z, et al. Higher mortality in pediatric liver transplant candidates with sarcopenia. Liver Transpl 2021;27(6):808–817. - PMC - PubMed
    1. Verhagen MV, Levolger S, Hulshoff JB, et al. Utility of preoperative CT-based body metrics in relation to postoperative complications in pediatric liver transplant recipients. Liver Transpl 2021. - PMC - PubMed

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