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Review
. 2022 Jan 1;34(1):19-28.
doi: 10.1097/CCO.0000000000000799.

Molecular genotyping of adrenocortical carcinoma: a systematic analysis of published literature 2019-2021

Salvatore Grisanti  1 , Deborah Cosentini  1 , Sandra Sigala  2 , Alfredo Berruti  1
Affiliations
Review

Molecular genotyping of adrenocortical carcinoma: a systematic analysis of published literature 2019-2021

Salvatore Grisanti et al. Curr Opin Oncol. .

Abstract

Purpose of review: comprehensive molecular characterization of adrenocortical carcinoma (ACC) through next-generation sequencing and bioinformatics analyses is expanding the number of targets with potential prognostic and therapeutic value. We performed a critical review of recent published literature on genotyping of ACC.

Recent findings: 423 studies were published between 2019 and 2021. After manual curation we summarized selected evidence in two thematic areas: germline deoxyribonucleic acid (DNA) variations, genomic alterations and prognosis.

Summary: the evolving genomic landscape of ACC requires target validation in terms of prognostic and predictive value within scientific consortia. Although the existing multiple driver genes are difficult targets in the perspective of precision oncology, alterations in DNA damage repair genes or in promoter hypermethylation could open new venues for repurposing of existing drugs in ACC.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Box 1
Box 1
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FIGURE 1
FIGURE 1
PRISMA flow diagram for systematic review of literature of genotyping of ACC (2019–2021). ACC, adrenocortical carcinoma.
See this image and copyright information in PMC

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