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Review
. 2022 Jan;40(1):4-16.
doi: 10.1002/cbf.3672. Epub 2021 Oct 21.

Melatonin: A smart molecule in the DNA repair system

Seyed Mostafa Mir  1 , Azadeh Aliarab  2 , Golnaz Goodarzi  3   4 , Moein Shirzad  5   6 , Seyyed Mehdi Jafari  1 , Durdi Qujeq  5   6 , Sadra Samavarchi Tehrani  3   4 , Jahanbakhsh Asadi  1
Affiliations
Review

Melatonin: A smart molecule in the DNA repair system

Seyed Mostafa Mir et al. Cell Biochem Funct. 2022 Jan.

Abstract

DNA repair is an important pathway for the protection of DNA molecules from destruction. DNA damage can be produced by oxidative reactive nitrogen or oxygen species, irritation, alkylating agents, depurination and depyrimidination; in this regard, DNA repair pathways can neutralize the negative effects of these factors. Melatonin is a hormone secreted from the pineal gland with an antioxidant effect by binding to oxidative factors. In addition, the effect of melatonin on DNA repair pathways has been proven by the literature. DNA repair is carried out by several mechanisms, of which homologous recombination repair (HRR) and non-homologous end-joining (NHEJ) are of great importance. Because of the importance of DNA repair in DNA integrity and the anticancer effect of this pathway, we presented the effect of melatonin on DNA repair factors regarding previous studies conducted in this area.

Keywords: DNA damage; DNA repair; cancer; melatonin; signalling pathways.

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References

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