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. 2021 Dec 10;374(6573):1343-1353.
doi: 10.1126/science.abl8912. Epub 2021 Oct 21.

Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine-boosted nonhuman primates

Kizzmekia S Corbett #  1 , Matthew Gagne #  1 , Danielle A Wagner  1 , Sarah O' Connell  1 , Sandeep R Narpala  1 , Dillon R Flebbe  1 , Shayne F Andrew  1 , Rachel L Davis  1 , Barbara Flynn  1 , Timothy S Johnston  1 , Christopher D Stringham  1 , Lilin Lai  2 , Daniel Valentin  3 , Alex Van Ry  3 , Zackery Flinchbaugh  3 , Anne P Werner  1 , Juan I Moliva  1 , Manjari Sriparna  1 , Sijy O'Dell  1 , Stephen D Schmidt  1 , Courtney Tucker  1 , Angela Choi  4 , Matthew Koch  4 , Kevin W Bock  5 , Mahnaz Minai  5 , Bianca M Nagata  5 , Gabriela S Alvarado  1 , Amy R Henry  1 , Farida Laboune  1 , Chaim A Schramm  1 , Yi Zhang  1 , Eun Sung Yang  1 , Lingshu Wang  1 , Misook Choe  1 , Seyhan Boyoglu-Barnum  1 , Shi Wei  1 , Evan Lamb  1 , Saule T Nurmukhambetova  1 , Samantha J Provost  1 , Mitzi M Donaldson  1 , Josue Marquez  1 , John-Paul M Todd  1 , Anthony Cook  3 , Alan Dodson  3 , Andrew Pekosz  6 , Eli Boritz  1 , Aurélie Ploquin  1 , Nicole Doria-Rose  1 , Laurent Pessaint  3 , Hanne Andersen  3 , Kathryn E Foulds  1 , John Misasi  1 , Kai Wu  4 , Andrea Carfi  4 , Martha C Nason  7 , John Mascola  1 , Ian N Moore  5 , Darin K Edwards  4 , Mark G Lewis  3 , Mehul S Suthar  2 , Mario Roederer  1 , Adrian McDermott  1 , Daniel C Douek  1 , Nancy J Sullivan  1 , Barney S Graham  1 , Robert A Seder  1
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Free article

Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine-boosted nonhuman primates

Kizzmekia S Corbett et al. Science. .
Free article

Abstract

Neutralizing antibody responses gradually wane against several variants of concern (VOCs) after vaccination with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine messenger RNA-1273 (mRNA-1273). We evaluated the immune responses in nonhuman primates that received a primary vaccination series of mRNA-1273 and were boosted about 6 months later with either homologous mRNA-1273 or heterologous mRNA-1273.β, which encompasses the spike sequence of the B.1.351 Beta variant. After boost, animals had increased neutralizing antibody responses across all VOCs, which was sustained for at least 8 weeks after boost. Nine weeks after boost, animals were challenged with the SARS-CoV-2 Beta variant. Viral replication was low to undetectable in bronchoalveolar lavage and significantly reduced in nasal swabs in all boosted animals, suggesting that booster vaccinations may be required to sustain immunity and protection.

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Update of

  • Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates.
    Corbett KS, Gagne M, Wagner DA, Connell SO, Narpala SR, Flebbe DR, Andrew SF, Davis RL, Flynn B, Johnston TS, Stringham C, Lai L, Valentin D, Van Ry A, Flinchbaugh Z, Werner AP, Moliva JI, Sriparna M, O'Dell S, Schmidt SD, Tucker C, Choi A, Koch M, Bock KW, Minai M, Nagata BM, Alvarado GS, Henry AR, Laboune F, Schramm CA, Zhang Y, Wang L, Choe M, Boyoglu-Barnum S, Shi W, Lamb E, Nurmukhambetova ST, Provost SJ, Donaldson MM, Marquez J, Todd JM, Cook A, Dodson A, Pekosz A, Boritz E, Ploquin A, Doria-Rose N, Pessaint L, Andersen H, Foulds KE, Misasi J, Wu K, Carfi A, Nason MC, Mascola J, Moore IN, Edwards DK, Lewis MG, Suthar MS, Roederer M, McDermott A, Douek DC, Sullivan NJ, Graham BS, Seder RA. Corbett KS, et al. bioRxiv [Preprint]. 2021 Aug 12:2021.08.11.456015. doi: 10.1101/2021.08.11.456015. bioRxiv. 2021. Update in: Science. 2021 Dec 10;374(6573):1343-1353. doi: 10.1126/science.abl8912. PMID: 34426813 Free PMC article. Updated. Preprint.

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