Comment
doi: 10.1016/j.neuron.2021.10.008.
Sharing is caring: The benefits of distributing protein aggregates among microglial networks
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- PMID: 34672979
- DOI: 10.1016/j.neuron.2021.10.008
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Comment
Sharing is caring: The benefits of distributing protein aggregates among microglial networks
Neuron.
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Abstract
The trafficking of protein aggregates through neural circuitries causes adverse outcomes, including propagation of pathology and toxicity in neurodegenerative diseases. In a recent issue of Cell, Scheiblich et al. (2021) describe an advantageous aggregate-sharing strategy in microglial networks that nurtures α-synuclein-loaded members back to health.
Keywords: microglia; mitochondria; neurodegenerative disorders; prion-like spreading; protein aggregation; α-synuclein.
Copyright © 2021. Published by Elsevier Inc.
Comment on
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Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.Cell. 2021 Sep 30;184(20):5089-5106.e21. doi: 10.1016/j.cell.2021.09.007. Epub 2021 Sep 22. Cell. 2021. PMID: 34555357 Free PMC article.