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Comment
. 2021 Oct 20;109(20):3231-3233.
doi: 10.1016/j.neuron.2021.09.022.

Uncovering the HARbingers of human brain evolution

Federica Mosti  1 , Debra L Silver  2
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Uncovering the HARbingers of human brain evolution

Federica Mosti et al. Neuron. .
Free article

Abstract

During evolution, humans acquired extensive genomic changes that collectively define unique features of our species, yet functions for these sequence variants are largely unknown. In this issue of Neuron, Girskis et al. comprehensively screen human accelerated regions (HARs) for enhancer activity in human-specific cortical development, creating a valuable online resource.

Keywords: cortex; enhancer; evolution; human accelerated.

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  • Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions.
    Girskis KM, Stergachis AB, DeGennaro EM, Doan RN, Qian X, Johnson MB, Wang PP, Sejourne GM, Nagy MA, Pollina EA, Sousa AMM, Shin T, Kenny CJ, Scotellaro JL, Debo BM, Gonzalez DM, Rento LM, Yeh RC, Song JHT, Beaudin M, Fan J, Kharchenko PV, Sestan N, Greenberg ME, Walsh CA. Girskis KM, et al. Neuron. 2021 Oct 20;109(20):3239-3251.e7. doi: 10.1016/j.neuron.2021.08.005. Epub 2021 Sep 2. Neuron. 2021. PMID: 34478631 Free PMC article.

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