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Comment
. 2021 Oct 20;109(20):3233-3235.
doi: 10.1016/j.neuron.2021.09.030.

MiR-218 steps down to a threshold of motor impairment

Victoria A Church  1 , Andrew S Yoo  2
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MiR-218 steps down to a threshold of motor impairment

Victoria A Church et al. Neuron. .
Free article

Abstract

In this issue of Neuron, Amin et al. (2021) generate genetic tools to titrate down levels of miR-218, a motor neuron-enriched microRNA, in vivo. Varying miR-218 dose alters target selection, results in distinct dose-response curves reflecting 3' UTR features, and reveals a miR-218 threshold below which motor neuron deficits emerge.

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Declaration of Interests The authors declare no competing interests.

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