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Editorial
. 2022 Jan;149(1):51-54.
doi: 10.1016/j.jaci.2021.09.034. Epub 2021 Oct 18.

BCG vaccine's off-target effects on allergic, inflammatory, and autoimmune diseases: Worth another shot?

Asimenia Angelidou  1 , Laure F Pittet  2 , Denise Faustman  3 , Nigel Curtis  4 , Ofer Levy  5
Affiliations
Editorial

BCG vaccine's off-target effects on allergic, inflammatory, and autoimmune diseases: Worth another shot?

Asimenia Angelidou et al. J Allergy Clin Immunol. 2022 Jan.
No abstract available

Keywords: Allergy; BCG vaccine; Bacille Calmette-Guérin vaccine; autoimmunity; inflammatory diseases.

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Conflict of interest statement

Disclosure of potential conflict of interest: O. Levy is a named inventor on vaccine adjuvant patent applications, as well as on an issued patent for an in vitro microphysiologic tissue construct platform for vaccine evaluation. The rest of the authors declare that they have no relevant conflicts of interest.

References

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    1. Pittet L, Messina N, Freyne B, Gardiner K, Abruzzo V, Francis K, et al. Prevention of infant eczema by neonatal bacille Calmette-Guérin vaccination: the MIS BAIR randomized controlled trial [e-pub ahead of print]. Allergy 10.1111/all.15022. - DOI - PubMed
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    1. Angelidou A, Diray-Arce J, Conti MG, Smolen KK, van Haren SD, Dowling DJ, et al. BCG as a case study for precision vaccine development: lessons from vaccine heterogeneity, trained immunity, and immune ontogeny. Front Microbiol 2020;11: 332. - PMC - PubMed
    1. Ban L, Zhang J, Wang L, Kuhtreiber W, Burger D, Faustman DL. Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism. Proc Natl Acad Sci USA 2008;105:13644–9. - PMC - PubMed

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