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. 2022 Jan:119:84-117.
doi: 10.1016/j.jhin.2021.07.014. Epub 2021 Oct 18.

Disinfection methods against SARS-CoV-2: a systematic review

C P Viana Martins  1 , C S F Xavier  2 , L Cobrado  3
Affiliations

Disinfection methods against SARS-CoV-2: a systematic review

C P Viana Martins et al. J Hosp Infect. 2022 Jan.

Abstract

Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease 2019, has caused millions of deaths worldwide. The virus is transmitted by inhalation of infectious particles suspended in the air, direct deposition on mucous membranes and indirect contact via contaminated surfaces. Disinfection methods that can halt such transmission are important in this pandemic and in future viral infections.

Aim: To highlight the efficacy of several disinfection methods against SARS-CoV-2 based on up-to-date evidence found in the literature.

Methods: Two databases were searched to identify studies that assessed disinfection methods used against SARS-CoV-2. In total, 1229 studies were identified and 60 of these were included in this review. Quality assessment was evaluated by the Office of Health Assessment and Translation's risk-of-bias tool.

Findings: Twenty-eight studies investigated disinfection methods on environmental surfaces, 16 studies investigated disinfection methods on biological surfaces, four studies investigated disinfection methods for airborne coronavirus, and 16 studies investigated methods used to recondition personal protective equipment (PPE).

Conclusions: Several household and hospital disinfection agents and ultraviolet-C (UV-C) irradiation were effective for inactivation of SARS-CoV-2 on environmental surfaces. Formulations containing povidone-iodine can provide virucidal action on the skin and mucous membranes. In the case of hand hygiene, typical soap bars and alcohols can inactivate SARS-CoV-2. Air filtration systems incorporated with materials that possess catalytic properties, UV-C devices and heating systems can reduce airborne viral particles effectively. The decontamination of PPE can be conducted safely by heat and ozone treatment.

Keywords: COVID-19; Coronavirus; Disinfection methods; SARS-CoV-2; Systematic review.

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Figure 1
PRISMA flow diagram of included articles. SARS-CoV-2, severe acute respiratory syndrome coronavirus-2.
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References

    1. Mofijur M., Fattah I.M.R., Alam M.A., Islam A.B.M.S., Ong H.C., Rahman S.M.A., et al. Impact of COVID-19 on the social, economic, environmental and energy domains: lessons learnt from a global pandemic. Sustain Prod Consum. 2021;26:343–359. - PMC - PubMed
    1. World Health Organization . WHO; Geneva: 2021. COVID-19 weekly epidemiological update.
    1. Lu R., Zhao X., Li J., Niu P., Yang B., Wu H., et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395:565–574. - PMC - PubMed
    1. Centers for Disease Control and Prevention . CDC; Atlanta, GA: 2021. Scientific brief: SARS-CoV-2 transmission. - PubMed
    1. Bulfone T.C., Malekinejad M., Rutherford G.W., Razani N. Outdoor transmission of SARS-CoV-2 and other respiratory viruses: a systematic review. J Infect Dis. 2021;223:550–561. - PMC - PubMed

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