Moderating effect of ppar-γ on the association of c-reactive protein and ischemic stroke in patients younger than 60

Abstract

Aim: The aim of this study was to evaluate the moderating effect of peroxisome proliferator activated receptor-γ (PPAR-γ) gene variants on the association of serum C-reactive protein level (CRP) and ischemic stroke (IS).

Material and methods: A total of 114 patients with IS and 135 healthy controls were included.

Results: After adjustment for age, sex, total cholesterol, LDL and HDL cholesterol, triglycerides, hypertension, smoking, body mass index and previous therapy with antihypertensive and/or statins, PPAR-γ had statistically significant moderating effect on association of serum CRP level and IS in patients younger than 60. In participants with PPAR CG or GG genotype level of CRP and IS were not statistically significantly associated (OR = 1.00; 95% CI 0.90-1.10; p = 0.933), but in participants with PPAR CC genotype, the association of serum CRP level and IS was significant (OR = 1.67; 95% CI 1.21-2.31; p = 0.002).

Conclusion: In patients with PPAR CC genotype the association of serum CRP level and IS was significant.

Keywords: Ischemic stroke; PPAR CC genotype; serum CRP level.