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Review
. 2021 Oct 21;17(10):e1009836.
doi: 10.1371/journal.ppat.1009836. eCollection 2021 Oct.

Pathogenesis insights from an ancient and ubiquitous spirochete

Jenifer Coburn  1 , Mathieu Picardeau  2 , Christopher W Woods  3   4 , Timothy Veldman  3 , David A Haake  5   6
Affiliations
Review

Pathogenesis insights from an ancient and ubiquitous spirochete

Jenifer Coburn et al. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

I have read the journal’s policy and the authors of this manuscript have the following competing interests: DAH has relevant intellectual property.

Figures

Fig 1
Fig 1. Overview of leptospirosis.
Potentially human pathogenic leptospires are maintained in zoonotic infection cycles in wildlife and domestic animals. Leptospires colonize the renal proximal tubule of reservoir hosts and are shed in the urine. Urine contamination of water and mud are common sources of human exposure. In humans and disease susceptible animals, leptospires disseminate and cause symptomatic disease ranging from mild to severe and, in some cases, death.
Fig 2
Fig 2. Massive species diversity.
(A) Phylogenetic tree showing the relatedness of the 64 Leptospira species. Leptospira species are clustered as non-pathogens, low-virulent pathogens, and virulent pathogens according to their virulence status in animal models, prevalence in severe infections, and presence of virulence factors. Node 1 indicates the node from which descend pathogenic species are most frequently involved in human disease. (B) Distribution of gene clusters in the P1 clade revealing an open pan-genome with a relatively high number of gene clusters found only in a single species. Adapted from Vincent and colleagues [5].
See this image and copyright information in PMC

References

    1. Picardeau M, Bulach DM, Bouchier C, Zuerner RL, Zidane N, Wilson PJ, et al.. Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis. PLoS ONE. 2008;3(2):e1607. doi: 10.1371/journal.pone.0001607 . - DOI - PMC - PubMed
    1. Xu Y, Zhu Y, Wang Y, Chang YF, Zhang Y, Jiang X, et al.. Whole genome sequencing revealed host adaptation-focused genomic plasticity of pathogenic Leptospira. Sci Rep. 2016;6:20020. Epub 2016/02/03. doi: 10.1038/srep20020 ; PubMed Central PMCID: PMC4735792. - DOI - PMC - PubMed
    1. Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, et al.. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLoS Negl Trop Dis. 2015;9(9):e0003898. Epub 2015/09/18. doi: 10.1371/journal.pntd.0003898 ; PubMed Central PMCID: PMC4574773. - DOI - PMC - PubMed
    1. Goarant C, Picardeau M, Morand S, McIntyre KM. Leptospirosis under the bibliometrics radar: evidence for a vicious circle of neglect. J Glob Health. 2019;9(1):010302. Epub 2019/01/04. doi: 10.7189/jogh.09.010302 ; PubMed Central PMCID: PMC6304173 form at www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare no conflict of interest. - DOI - PMC - PubMed
    1. Vincent AT, Schiettekatte O, Goarant C, Neela VK, Bernet E, Thibeaux R, et al.. Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics. PLoS Negl Trop Dis. 2019;13(5):e0007270. Epub 2019/05/24. doi: 10.1371/journal.pntd.0007270 ; PubMed Central PMCID: PMC6532842. - DOI - PMC - PubMed

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