Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan;28(1):175-177.
doi: 10.1111/cns.13745. Epub 2021 Oct 21.

Association analysis of SYT11, FGF20, GCH1 rare variants in Parkinson's disease

Jia-Li Pu  1 , Zhi-Hao Lin  1 , Ran Zheng  1 , Yi-Qun Yan  1 , Nai-Jia Xue  1 , Xin-Zhen Yin  1 , Bao-Rong Zhang  1
Affiliations

Association analysis of SYT11, FGF20, GCH1 rare variants in Parkinson's disease

Jia-Li Pu et al. CNS Neurosci Ther. 2022 Jan.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Schematic of human GCH1 and pathogenetic analysis of c.C552T, p.R186C variant. (A) The c.C552T, p.R186C variant locates in GCH1 gene and GCH1 protein. (B) The position and the surrounding sequence of GCH1 p.R186C are highly conserved across different species. (C) Pathogenicity prediction of c.C552T, p.R186C variant in silico. Threshold values for deleteriousness: CADD greater than 15; Polyphen2 greater than 0.86; SIFT less than 0.05 [Colour figure can be viewed at wileyonlinelibrary.com]
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Shen YT, Wang JW, Wang M, et al. BST1 rs4698412 allelic variant increases the risk of gait or balance deficits in patients with Parkinson's disease. CNS Neurosci Ther. 2019;25(4):422‐429. - PMC - PubMed
    1. Gao T, Wu J, Zheng R, et al. Assessment of three essential tremor genetic loci in sporadic Parkinson's disease in Eastern China. CNS Neurosci Ther. 2020;26(4):448‐452. - PMC - PubMed
    1. Rudakou U, Yu E, Krohn L, et al. Targeted sequencing of Parkinson's disease loci genes s SYT11, FGF20 and other associations. Brain. 2020;144(2):462‐472. - PMC - PubMed
    1. Postuma RB, Berg D, Stern M, et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov Disord. 2015;30(12):1591‐1601. - PubMed
    1. Xie Z, Long J, Liu J, Chai Z, Kang X, Wang C. Molecular mechanisms for the coupling of endocytosis to exocytosis in neurons. Front Mol Neurosci. 2017;10:47. - PMC - PubMed