Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Oct 21;18(1):15.
doi: 10.1186/s12982-021-00104-5.

RSV: perspectives to strengthen the need for protection in all infants

Jose Antonio Navarro Alonso  1 , Louis J Bont  2 , Elena Bozzola  3 , Egbert Herting  4 , Federico Lega  5 , Silke Mader  6 , Marta C Nunes  7 , Octavio Ramilo  8 , George Valiotis  9 , Catherine Weil Olivier  10 , Ann Yates  11 , Saul N Faust  12   13
Affiliations
Review

RSV: perspectives to strengthen the need for protection in all infants

Jose Antonio Navarro Alonso et al. Emerg Themes Epidemiol. .

Abstract

Respiratory syncytial virus (RSV)-the most common viral cause of bronchiolitis-is a significant cause of serious illness among young children between the ages of 0-5 years and is especially concerning in the first year of life. Globally, RSV is a common cause of childhood acute lower respiratory illness (ALRI) and a major cause of hospital admissions in young children and infants and represents a substantial burden for health-care systems. This burden is strongly felt as there are currently no effective preventative options that are available for all infants. However, a renaissance in RSV prevention strategies is unfolding, with several new prophylactic options such as monoclonal antibodies and maternal vaccinations that are soon to be available. A key concern is that health decision makers and systems may not be ready to take full advantage of forthcoming technological innovations. A multi-stakeholder approach is necessary to bridge data gaps to fully utilise upcoming options. Knowledge must be made available at multiple levels to ensure that parents and doctors are aware of preventative options, but also to ensure that stakeholders and policymakers are given the necessary information to best advise implementation strategies.

Keywords: Global childhood disease burden; Infant and child health; Infant mortality; RSV, Respiratory syncytial virus; RSV-ALRI, RSV-associated acute lower respiratory illness; Vaccine.

PubMed Disclaimer

Conflict of interest statement

An honorarium was paid to SNFs institution for his participation in the expert group but SNF received no personal payments of any kind. SNF has acted as clinical trial investigator on behalf of his hospital for GSK, Janssen (J&J), Regeneron and Medimmune (AstraZeneca) in the field of RSV vaccines and monoclonal antibodies but SNF received no personal payment of any kind. LJB has regular interaction with pharmaceutical and other industrial partners. He has not received personal fees or other personal benefits. University Medical Centre Utrecht (UMCU) has received major funding (> €1,00,000 per industrial partner) for investigator initiated studies from AbbVie, MedImmune, Janssen, the Bill and Melinda Gates Foundation, Nutricia (Danone) and MeMed Diagnostics. UMCU has received major cash or in kind funding as part of the public private partnership Innovative Medicines Initiative-funded Respiratory Syncytial Virus Consortium in Europe project from GSK, Novavax, Janssen, AstraZeneca, Pfizer and Sanofi. UMCU has received major funding by Julius Clinical for participating in the International Network for Optimal Resistance Monitoring of RSV study sponsored by MedImmune. UMCU has received minor funding for participation in trials by Regeneron and Janssen from 2015 to 2017 (total annual estimate < €20,000). UMCU received minor funding for consultation and invited lectures by AbbVie, MedImmune, Ablynx, Bavaria Nordic, MabXience, Novavax, Pfizer and Janssen (total annual estimate < €20,000). LJB is the founding chairman of the ReSViNET Foundation. SM reports a sponsorship agreement between SP and EFCNI.

References

    1. Shi T, McAllister D, O'Brien K, Simoes E, Madhi S, Gessner B, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet. 2017;390(10098):946–958. doi: 10.1016/S0140-6736(17)30938-8. - DOI - PMC - PubMed
    1. Griffin MP, Yuan Y, Takas T, Domachowske JB, Madhi SA, Manzoni P, et al. Single-dose nirsevimab for prevention of RSV in preterm infants. N Engl J Med. 2020;383(5):415–425. doi: 10.1056/NEJMoa1913556. - DOI - PubMed
    1. Kandeil W, Savic M, Ceregido MA, Guignard A, Kuznetsova A, Mukherjee P. Immune interference (blunting) in the context of maternal immunization with Tdap-containing vaccines: is it a class effect? Expert Rev Vaccines. 2020;19(4):341–352. doi: 10.1080/14760584.2020.1749597. - DOI - PubMed
    1. Jarvis JR, Dorey RB, Warricker FDM, Alwan NA, Jones CE. The effectiveness of influenza vaccination in pregnancy in relation to child health outcomes: systematic review and meta-analysis. Vaccine. 2020;38(7):1601–1613. doi: 10.1016/j.vaccine.2019.12.056. - DOI - PubMed
    1. Campbell PT, Geard N, Hogan AB. Modelling the household-level impact of a maternal respiratory syncytial virus (RSV) vaccine in a high-income setting. BMC Med. 2020;18(1):319. doi: 10.1186/s12916-020-01783-8. - DOI - PMC - PubMed

LinkOut - more resources