A roadmap to creating ferroptosis-based medicines

Abstract

Ferroptosis is a regulated form of non-apoptotic cell death implicated in pathological settings. To be exploited clinically, ferroptosis requires reagents that unequivocally detect ferroptosis in human and animal tissues. Such tools may enable development of ferroptosis-based medicines for diverse diseases.

Figure 1:

Major ferroptosis regulators and small molecule modulators. Components inducing ferroptosis are depicted in green, and components inhibiting ferroptosis are shown in pink. Small molecules are shown as hexagons. pUbiquinol: ubiquinol in plasma membrane; mUbiquinol: mitochondrial ubiquinol.

Figure 2:

Ferroptosis detection and classification. Sample staining with ferroptosis specific reagents and subsequent artificial intelligence methods for image analysis to specifically classify ferroptosis in vivo.