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. 2021 Oct 7:14:4189-4197.
doi: 10.2147/DMSO.S326070. eCollection 2021.

Trends in Serum Lipid Profiles Among Korean Adolescents, 2007-2018

Da-Young Jeong  1 , Shin-Hye Kim  1 , Moon Young Seo  2 , Sin Young Kang  1 , Mi Jung Park  1
Affiliations

Trends in Serum Lipid Profiles Among Korean Adolescents, 2007-2018

Da-Young Jeong et al. Diabetes Metab Syndr Obes. .

Abstract

Purpose: An adverse lipid profile in adolescence often persists into adulthood, resulting in cardiovascular disease. We aimed to investigate the trends in the prevalence of adverse lipid profiles among Korean adolescents from 2007 to 2018.

Patients and methods: The data were obtained from 9044 adolescents aged 10-19 years who participated in the Korean National Health and Nutrition Examination Surveys (KNHANES) from 2007 to 2018. Fasting serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels were analyzed.

Results: Significantly increasing trends in age-standardized prevalence of hypercholesterolemia [from 5.6% to 9.4% in boys (P = 0.004); from 8.1% to 12.4% in girls (P = 0.01)] and hyper-LDL-cholesterolemia [from 4.3% to 8.0% in boys (P = 0.003); from 6.6% to 9.7% in girls (P = 0.035)] were noted in both sexes. In contrast, the prevalence of hypo-HDL-cholesterolemia decreased significantly from 20.0% to 12.5% in boys (<0.001) and from 12.4% to 6.9% in girls (P < 0.001). There were no significant changes in the prevalence of hypertriglyceridemia and hyper-non-HDL-cholesterolemia in both sexes. Accordingly, the overall prevalence of dyslipidemia showed only a modest decline in boys (from 31.8% to 28.7%) and a stable trend in girls (from 28.9% to 28.2%).

Conclusion: The prevalence of hypercholesterolemia and hyper-LDL-cholesterolemia increased and that of hypo-HDL-cholesterolemia decreased among Korean adolescents over the recent 12 years. Further studies are needed to explain these trends and possible associations with lifestyle factors.

Keywords: KNHANES; cholesterol; dyslipidemia; hypercholesterolemia; prevalence.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Trends in age-adjusted mean serum lipid profiles by sex in Korean adolescents from the nationwide survey data from 2007–2018.
Figure 2
Figure 2
Trends in prevalence of adverse lipid profiles in Korean adolescents from the nationwide survey data from 2007–2018.
See this image and copyright information in PMC

References

    1. Khan MA, Hashim MJ, Mustafa H, et al. Global epidemiology of ischemic heart disease: results from the Global Burden of Disease Study. Cureus. 2020;12:e9349. - PMC - PubMed
    1. Shin JH, Cheong JI, Cheuh HW, Yoo JH. Limitations of current screening methods for lipid disorders in Korean adolescents and a proposal for an effective detection method: a nationwide, cross-sectional study. Ann Pediatr Endocrinol Metab. 2020;25:265–271. doi:10.6065/apem.2040098.049 - DOI - PMC - PubMed
    1. Frontini MG, Srinivasan SR, Xu J, Tang R, Bond MG, Berenson GS. Usefulness of childhood non-high density lipoprotein cholesterol levels versus other lipoprotein measures in predicting adult subclinical atherosclerosis: the Bogalusa Heart Study. Pediatrics. 2008;121:924–929. doi:10.1542/peds.2007-1472 - DOI - PubMed
    1. Kim JH, Moon JS. Secular trends in pediatric overweight and obesity in Korea. J Obes Metab Syndr. 2020;29:12–17. doi:10.7570/jomes20002 - DOI - PMC - PubMed
    1. Kim SH, Ahn BC, Joung H, Park MJ. Lipid profiles and prevalence of dyslipidemia in Korean adolescents. Endocrinol Metab. 2012;27:208–216. doi:10.3803/EnM.2012.27.3.208 - DOI