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Clinical Trial
. 2021 Oct 10:13:1807-1822.
doi: 10.2147/NSS.S326762. eCollection 2021.

Impact of Acupuncture on Sleep and Comorbid Symptoms for Chronic Insomnia: A Randomized Clinical Trial

Cong Wang #  1 , Wen-Lin Xu #  1 , Guan-Wu Li  2 , Cong Fu  1 , Jin-Jin Li  1 , Jing Wang  1 , Xin-Yu Chen  3 , Zhen Liu  1 , Yun-Fei Chen  1
Affiliations
Clinical Trial

Impact of Acupuncture on Sleep and Comorbid Symptoms for Chronic Insomnia: A Randomized Clinical Trial

Cong Wang et al. Nat Sci Sleep. .

Abstract

Study objectives: To evaluate the efficacy and safety of acupuncture at HT 7 (Shenmen) and KI 7 (Fuliu) on sleep and comorbid symptoms for chronic insomnia.

Methods and design: A randomized, single-blind, parallel and sham-controlled trial consisted of an acupuncture group (n = 41) and a sham acupuncture group (n = 41). Setting: a tertiary hospital of integrated Chinese and Western medicine. Participants: 82 subjects with chronic insomnia based on the International Classification of Sleep Disorders, Third Edition (ICSD-3). Interventions: a 10-session acupuncture treatment at bilateral HT 7 and KI 7 or sham acupoints with shallow needling was performed over 3 weeks. Measurements: the Pittsburgh sleep quality index (PSQI) and insomnia severity index (ISI) were evaluated at baseline, posttreatment, and at two follow-ups as the primary outcome measures. Polysomnography (PSG) on two consecutive nights, the Beck anxiety inventory (BAI), the Beck depression inventory (BDI) fatigue severity scale (FSS) and the Epworth sleepiness scale (ESS) were evaluated at baseline and posttreatment as the secondary outcome measures.

Results: After the treatments, PSQI scores decreased by 5.04 in the acupuncture group and 2.92 in the sham acupuncture group. ISI scores decreased by 7.65 in the acupuncture group and 5.05 in the sham acupuncture group. The between-group differences in the primary outcome measures posttreatment were statistically significant. However, no differences were found between the two groups during the two follow-ups. Regarding the PSG data, there were significantly lower levels of sleep onset latency (SOL), a lower percentage of sleep stage N1 and a higher percentage of sleep stage N3 in the acupuncture group than in the sham acupuncture group. After treatment, there were lower levels of comorbid symptoms (BAI, BDI, FSS and ESS) in both groups. However, no significant differences were observed between the groups.

Conclusion: Acupuncture at HT 7 and KI 7 is an effective and safe nonpharmacologic intervention option for chronic insomnia.

Clinical trial registration: The study was registered at the Chinese Clinical Trial Registry, registration ID: ChiCTR1900023787, China.

Keywords: acupuncture; chronic insomnia; randomized clinical trial; sleep and comorbid symptoms.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Acupoints for the acupuncture and sham acupuncture groups.
Figure 2
Figure 2
Flow of subjects randomized to acupuncture or sham acupuncture.
Figure 3
Figure 3
Mean PSQI scores of the two groups during the study period.
Figure 4
Figure 4
Mean ISI scores of the two groups during the study period.
See this image and copyright information in PMC

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