Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021:1:36.
doi: 10.1038/s43856-021-00037-9. Epub 2021 Oct 5.

Next steps in the early detection of ovarian cancer

Affiliations

Next steps in the early detection of ovarian cancer

Robert C Bast et al. Commun Med (Lond). 2021.

Abstract

A recent ovarian cancer screening trial found no reduction in mortality, despite increased detection of early stage disease. Here, we discuss these findings and examine next steps to develop more effective approaches for the early detection of ovarian cancer.

PubMed Disclaimer

Conflict of interest statement

Competing interests Dr. Bast receives royalties for the discovery of CA125 from Fujirebio Diagnostics Inc. The other authors declare no competing interests.

References

    1. Menon U, et al. Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet. 2021;397:2182–2193. doi: 10.1016/S0140-6736(21)00731-5. - DOI - PMC - PubMed
    1. Jacobs IJ, et al. Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet. 2016;387:945–956. doi: 10.1016/S0140-6736(15)01224-6. - DOI - PMC - PubMed
    1. Fan D, et al. A novel salt inducible kinase 2 inhibitor, ARN-3261, sensitizes ovarian cancer cell lines and xenografts to carboplatin. Cancers. 2021;13:446. doi: 10.3390/cancers13030446. - DOI - PMC - PubMed
    1. Lu KH, et al. A 2-stage ovarian cancer screening strategy using the risk of ovarian cancer algorithm (ROCA) identifies early-stage incident cancers and demonstrates high positive predictive value. Cancer. 2013;119:3454–3461. doi: 10.1002/cncr.28183. - DOI - PMC - PubMed
    1. Stott W, et al. Sonographers’ self‐reported visualization of normal postmenopausal ovaries on transvaginal ultrasound is not reliable: results of expert review of archived images in UKCTOCS. Ultrasound Obstet. Gynecol. 2018;51:401–408. doi: 10.1002/uog.18836. - DOI - PMC - PubMed