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Review
. 2022 Feb;237(2):1171-1181.
doi: 10.1002/jcp.30616. Epub 2021 Oct 21.

Mechanotransduction in meniscus fibrochondrocytes: What about caveolae?

Margaret J Vyhlidal  1 , Adetola B Adesida  1   2
Affiliations
Review

Mechanotransduction in meniscus fibrochondrocytes: What about caveolae?

Margaret J Vyhlidal et al. J Cell Physiol. 2022 Feb.

Abstract

Meniscus fibrochondrocytes (MFCs) are an important cell population responsible for regulating the biomechanical properties of the knee meniscus. Despite their significance, not much is known about them, including how they sense and respond to mechanical stimuli. Due to the mechanical nature of the knee joint, it is therefore paramount to our understanding of the meniscus that its mechanotransductive mechanism be elucidated. In this review, we will summarize the current knowledge on mechanotransduction in MFCs and highlight the relevance of caveolae in lieu of a recent discovery. Additionally, we will discuss the importance of future studies in this area to help advance the field of meniscus research.

Keywords: caveolae; mechanotransduction; meniscus; meniscus fibrochondrocytes; signal transduction.

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References

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