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Review
. 2021 Sep 22;11(10):647.
doi: 10.3390/metabo11100647.

Metabolomics, Microbiota, and In Vivo and In Vitro Biomarkers in Type 2 Severe Asthma: A Perspective Review

Cristiano Caruso  1 , Stefania Colantuono  1   2 , Alberto Nicoletti  3 , Stefania Arasi  4 , Davide Firinu  5 , Antonio Gasbarrini  2 , Angelo Coppola  6   7 , Loreta Di Michele  8
Affiliations
Review

Metabolomics, Microbiota, and In Vivo and In Vitro Biomarkers in Type 2 Severe Asthma: A Perspective Review

Cristiano Caruso et al. Metabolites. .

Abstract

Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient; thus, it could be a new approach for the management of severe asthma that considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events. Metabolomics is the systematic study of low molecular weight (bio)chemicals in a given biological system and offers a powerful approach to biomarker discovery and elucidating disease mechanisms. In this point of view, metabolomics could play a key role in targeting precision medicine.

Keywords: asthma; metabolomics; microbiota.

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Conflict of interest statement

The authors declare no conflict of interest.

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