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. 2021 Oct 11;8(10):59.
doi: 10.3390/medicines8100059.

COVID-19 Infection and Neuropathological Features

Leonardo Freire-de-Lima  1 , Aline Miranda Scovino  2   3 , Leonardo Marques da Fonseca  1 , Camilla Cristie Barreto Menezes  3 , Carlos Antonio do Nascimento Santos  1 , Marco Edilson Freire de Lima  4 , Debora Decote-Ricardo  5 , Matheus Freire-de-Lima  1 , Kelli Monteiro da Costa  1 , Jhenifer Santos Dos Reis  1 , Marcos André Rodrigues da Costa Santos  1 , Celio Geraldo Freire-de-Lima  1 , Alexandre Morrot  3   6
Affiliations

COVID-19 Infection and Neuropathological Features

Leonardo Freire-de-Lima et al. Medicines (Basel). .

Abstract

The pathology associated with COVID-19 infection is progressively being revealed. Recent postmortem assessments have revealed acute airway inflammation as well as diffuse alveolar damage, which bears resemblance to severe acute respiratory syndromes induced by both SARS-CoV and MERS-CoV infections. Although recent papers have highlighted some neuropathologies associated with COVID-19 infection, little is known about this topic of great importance in the area of public health. Here, we discuss how neuroinflammation related to COVID-19 could be triggered by direct viral neuroinvasion and/or cytokine release over the course of the infection.

Keywords: COVID-19 infection; autoantibodies; neuroinflammation; neuropathology.

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Conflict of interest statement

The authors declare no conflict of interest.

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