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Review
. 2021 Oct 9;11(10):770.
doi: 10.3390/membranes11100770.

Electrospun Medicated Nanofibers for Wound Healing: Review

Xinkuan Liu  1 , Haixia Xu  1 , Mingxin Zhang  1 , Deng-Guang Yu  1   2
Affiliations
Review

Electrospun Medicated Nanofibers for Wound Healing: Review

Xinkuan Liu et al. Membranes (Basel). .

Abstract

With the increasing demand for wound care and treatment worldwide, traditional dressings have been unable to meet the needs of the existing market due to their limited antibacterial properties and other defects. Electrospinning technology has attracted more and more researchers' attention as a simple and versatile manufacturing method. The electrospun nanofiber membrane has a unique structure and biological function similar to the extracellular matrix (ECM), and is considered an advanced wound dressing. They have significant potential in encapsulating and delivering active substances that promote wound healing. This article first discusses the common types of wound dressing, and then summarizes the development of electrospun fiber preparation technology. Finally, the polymers and common biologically active substances used in electrospinning wound dressings are summarized, and portable electrospinning equipment is also discussed. Additionally, future research needs are put forward.

Keywords: electrospinning; nanocomposite; nanostructure; wound dressing.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Statistics of literature retrieval on the “Web of Science” platform with the subject of “Wound dressing” and “Electrospun wound dressing”, respectively.
Figure 2
Figure 2
Structure of different wound dressing.
Figure 3
Figure 3
Process classification of electrospinning technology (adapted from [72], with permission from MDPI, 2021).
Figure 4
Figure 4
Common polymers used in electrospun wound dressings.
Figure 5
Figure 5
(A) Chitosan extracted from natural sources and developed into electrospun fiber membranes and its application in wound healing [34]; (B) a schematic diagram of the wound healing process of a drug-loaded chitosan dressing [103]; (C) the sources of fibroin [107]; (D) preparation and in vitro and in vivo study of HA/SF-ZO nanofiber by coaxial electrospinning [108].
Figure 6
Figure 6
(A) Electrospinning PCL/QCSP nanofiber membrane with anti-bacteria, anti-oxidant, stretchability and electroactivity [113]; (B) preparation of coaxial electrospinning nanofiber mat and its excellent properties [117].
Figure 7
Figure 7
(A) PHBV/nCeO2 nanofiber membrane in cell adhesion, migration and wound healing research [124]; (B) the electrospun antibacterial bilayer nanofiber scaffold is used to promote the various characterization analysis of the full-thickness skin defect healing in mice [126].
Figure 8
Figure 8
(A) In situ electrospinning process [148]; (B) [149] (a) schematic diagram of portable electrospinning device and preparation of EPU/FPU/thymol nanofiber; (b) schematic diagram of the breathable, waterproof and antibacterial functions of EPU/FPU/Thymol nanofiber.
Figure 9
Figure 9
Structure, performance and application of electrospun nanofiber.
See this image and copyright information in PMC

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