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Review
. 2022 Jan;29(2):1634-1644.
doi: 10.1007/s11356-021-17027-y. Epub 2021 Oct 22.

Di(2-ethylhexyl) phthalate (DEHP) and thyroid: biological mechanisms of interference and possible clinical implications

Xueting Zhang  1 , Wen Qi  1 , Qi Xu  1 , Xu Li  1 , Liting Zhou  1 , Lin Ye  2
Affiliations
Review

Di(2-ethylhexyl) phthalate (DEHP) and thyroid: biological mechanisms of interference and possible clinical implications

Xueting Zhang et al. Environ Sci Pollut Res Int. 2022 Jan.

Abstract

Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental endocrine disruptor. DEHP can be absorbed into the human body through the air, food, water, and skin. After entering the human body, DEHP is rapidly converted to mono(2-ethylhexyl) phthalate (MEHP) with greater toxicity than DEHP. An increasing number of studies indicates that DEHP or MEHP can damage the thyroid tissue and disrupt the function, but the mechanisms remain unclear. This article reviews the toxicity of DEHP on thyroid structures and functions and summarizes the potential mechanisms to provide evidence for preventing the thyroid-related diseases.

Keywords: DEHP; Estrogen receptor; Notch; Thyroid; Thyroid hormones.

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