Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Mar;17(2):593-596.
doi: 10.1007/s11739-021-02865-y. Epub 2021 Oct 22.

Oxygen-ozone treatment and COVID-19: antioxidants targeting endothelia lead the scenery

Angelica Varesi  1   2 , Salvatore Chirumbolo  3 , Giovanni Ricevuti  4
Affiliations
Comment

Oxygen-ozone treatment and COVID-19: antioxidants targeting endothelia lead the scenery

Angelica Varesi et al. Intern Emerg Med. 2022 Mar.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig 1
Fig 1
Sars-CoV-2 infection causes an imbalance in redox homeostasis that can be re-established by O2/O3 therapy. Nrf2 antioxidant pathway reduction, NF-kB-mediated inflammation increase, high neutrophil to lymphocyte ratio and more circulating NETs are all consequences of SARS-CoV2 infection. The subsequent ROS bursts favors the cytokine storm together with NF-kB pathway, thus further enhancing inflammation. At the same time, all these events lead eventually to endothelial activation and thrombus formation, contributing to COVID-19-induced complications, such as pulmonary embolism, stroke, deep vein thrombosis and cardiovascular complications. The antioxidant, anti-inflammatory and anti-thrombotic effects of oxygen–ozone therapy can re-establish the right redox balance, reduce the inflammation and avoid the COVID-19-mediated thromboembolism, hence restoring tissue homeostasis Adapted from Laforge M, et al. Tissue damage from neutrophil-induced oxidative stress in COVID-19. Nat Rev Immunol. 2020;20:515–516. https://doi.org/10.1038/s41577-020-0407-1
See this image and copyright information in PMC

Comment on

References

    1. Bonaventura A, Vecchié A, Dagna L, Martinod K, Dixon DL, Van Tassell BW, Dentali F, Montecucco F, Massberg S, Levi M, Abbate A. Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Nat Rev Immunol. 2021;21(5):319–329. doi: 10.1038/s41577-021-00536-9. - DOI - PMC - PubMed
    1. Franzini M, Valdenassi L, Ricevuti G, Chirumbolo S, Depfenhart M, Bertossi D, Tirelli U. Oxygen-ozone (O2–O3) immunoceutical therapy for patients with COVID-19 Preliminary evidence reported. Int Immunopharmacol. 2020;88:106879. doi: 10.1016/j.intimp.2020.106879. - DOI - PMC - PubMed
    1. Chirumbolo S, Valdenassi L, Simonetti V, Bertossi D, Ricevuti G, Franzini M, Pandolfi S. Insights on the mechanisms of action of ozone in the medical therapy against COVID-19. Int Immunopharmacol. 2021;96:107777. doi: 10.1016/j.intimp.2021.107777. - DOI - PMC - PubMed
    1. Hua J, Qian C, Luo Z, Li Q, Wang F. Invasive mechanical ventilation in COVID-19 patient management: the experience with 469 patients in Wuhan. Crit Care. 2020;24(1):348. doi: 10.1186/s13054-020-03044-9. - DOI - PMC - PubMed
    1. Marfella R, Paolisso P, Sardu C, Palomba L, D'Onofrio N, Cesaro A, Barbieri M, Rizzo MR, Sasso FC, Scisciola L, Turriziani F, Galdiero M, Pignataro D, Minicucci F, Trotta MC, D'Amico M, Mauro C, Calabrò P, Balestrieri ML, Signioriello G, Barbato E, Galdiero M, Paolisso G. SARS-COV-2 colonizes coronary thrombus and impairs heart microcirculation bed in asymptomatic SARS-CoV-2 positive subjects with acute myocardial infarction. Crit Care. 2021;25(1):217. doi: 10.1186/s13054-021-03643-0. - DOI - PMC - PubMed