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Review
. 2021 Oct 2;10(10):1571.
doi: 10.3390/antiox10101571.

Mechanistic Aspects of Apiaceae Family Spices in Ameliorating Alzheimer's Disease

Niti Sharma  1 , Mario A Tan  2 , Seong Soo A An  1
Affiliations
Review

Mechanistic Aspects of Apiaceae Family Spices in Ameliorating Alzheimer's Disease

Niti Sharma et al. Antioxidants (Basel). .

Abstract

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases worldwide. In an effort to search for new strategies for treating AD, natural products have become candidates of choice. Plants are a rich source of bioactive and effective compounds used in treating numerous diseases. Various plant extracts are known to display neuroprotective activities by targeting different pathophysiological pathways in association with the diseases, such as inhibiting enzymes responsible for degrading neurotransmitters, reducing oxidative stress, neuroprotection, inhibiting amyloid plaque formation, and replenishing mitochondrial function. This review presented a comprehensive evaluation of the available scientific literature (in vivo, in vitro, and in silico) on the neuroprotective mechanisms displayed by the extracts/bioactive compounds from spices belonging to the Apiaceae family in ameliorating AD.

Keywords: Alzheimer’s disease; amyloid-beta; antioxidant; enzyme inhibitors; essential oils; natural products; neuroprotective; spices.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structures of some important bioactive compounds present in spices (Apiaceae family).
Figure 2
Figure 2
Neuroprotective mechanisms in Alzheimer’s disease displayed by spice extracts and/or natural products belonging to the Apiaceae family.
See this image and copyright information in PMC

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