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. 2021 Oct 7;10(10):1579.
doi: 10.3390/antiox10101579.

Development of an Optimized Drying Process for the Recovery of Bioactive Compounds from the Autumn Fruits of Berberis vulgaris L. and Crataegus monogyna Jacq

Cadmiel Moldovan  1 , Oleg Frumuzachi  1 , Mihai Babotă  1 , Luigi Menghini  2 , Stefania Cesa  3 , Alexandru Gavan  1 , Cristian R Sisea  4   5 , Corneliu Tanase  6 , Maria Inês Dias  7 , Carla Pereira  7 , Isabel C F R Ferreira  7 , Gianina Crișan  1 , Andrei Mocan  1   4 , Lillian Barros  7
Affiliations

Development of an Optimized Drying Process for the Recovery of Bioactive Compounds from the Autumn Fruits of Berberis vulgaris L. and Crataegus monogyna Jacq

Cadmiel Moldovan et al. Antioxidants (Basel). .

Abstract

Hot air drying has proven to be an efficient method to preserve specific edible plant materials with medicinal properties. This is a process involving chemical, physical, and biological changes in plant matrices. Understanding these processes will lead to an improvement in the yields of bioactive compounds. This study aims to optimize the drying process of two species' fruits used in folk medicine, Berberis vulgaris and Crataegus monogyna. The optimized extracts' antioxidant capacity was assessed using various assays, with the barberry extract showing very good activity (50.85, 30.98, and 302.45 mg TE/g dw for DPPH, TEAC, and FRAP assays, respectively). Both species exerted good fungal α-glucosidase inhibitory activity (IC50 = 0.34 and 0.56 mg/mL, respectively) but no activity on mammalian α-glucosidase. Additionally, this study identified and quantified the main bioactive compounds. The results presented herein are a breakthrough in industrializing this drying process. Additional studies are necessary to mechanistically understand the drying process involved in these plant materials.

Keywords: antioxidant activity; autumn fruits; barberry; drying process optimization; hawthorn.

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Conflict of interest statement

There are no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Residual mass percentage versus drying time for temperatures of 50, 60, and 70 °C in B. vulagris (A) and C. monogyna (B).
Figure 2
Figure 2
(A) Optimal temperature conditions represented in design spaces as a function of time for drying processes, (B) 3D-response surface plots: The interdependence between critical drying process parameters (temperature and time of drying) with the percent of residual mass for B. vulgaris and C. monogyna samples.
Figure 3
Figure 3
Total phenolic content (TPC), total flavonoid content (TFC), and DPPH radical scavenging activity as a function of time regarding the temperature conditions of drying plant samples (50, 60, and 70 °C).
Figure 4
Figure 4
Chromatographic profile of B. vulgaris and C. monogyna recorded at 280 nm ((A) and (C), respectively) and 370 nm ((B) and (D), respectively).
Figure 5
Figure 5
Graphic representation of logarithm of extract concentration (log10 [c]) versus the percent of enzyme inhibition (%I) of B. vulgaris (A) and C. monogyna (B) extracts.
See this image and copyright information in PMC

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