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. 2021 Oct 16;11(10):2985.
doi: 10.3390/ani11102985.

Effects of Feeding a Hypoallergenic Diet with a Nutraceutical on Fecal Dysbiosis Index and Clinical Manifestations of Canine Atopic Dermatitis

Eleonora Elisa Alice Guidi  1 , Alessandro Gramenzi  2 , Paola Persico  3 , Roberta Di Prinzio  4 , Daniele Di Simone  5 , Luisa Cornegliani  6
Affiliations

Effects of Feeding a Hypoallergenic Diet with a Nutraceutical on Fecal Dysbiosis Index and Clinical Manifestations of Canine Atopic Dermatitis

Eleonora Elisa Alice Guidi et al. Animals (Basel). .

Abstract

Background: an imbalance of the intestinal microbiota can cause health problems in the gastrointestinal tract and in other organs. Canine Atopic Dermatitis (CAD) is a genetically predisposed, inflammatory and pruritic allergic skin disease with multifactorial etiology and multimodal treatment. The aim of this study was to assess the effect of a nutraceutical product on Dysbiotic Index (DI) and the skin lesions of atopic dogs.

Methods: a nutraceutical product was administered to 32 dogs with CAD. The product was associated with a standardized hypoallergenic diet for 60 days; the dietary regimen continued for 120 days, while ongoing therapies remained unchanged. Values of Visual Analogic Scale (VAS), Canine Atopic Dermatitis Lesional Index (CADLI) and DI were evaluated on day 0, 60, 120.

Results: all the 32 dogs showed a statistically significant decrease (p < 0.001) to V60 of VAS and CADLI, which persisted and increased to V120 when diet alone was continued. The decrease in the DI value was also statistically significant (p < 0.001).

Conclusion: the intake of nutraceutical associated with diet resulted in a decrease in the index of intestinal dysbiosis, with an improvement in the subjective severity of cutaneous lesions.

Keywords: atopic dermatitis; dog; gut microbiota; nutraceutical; skin.

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Conflict of interest statement

In accordance with the NBF Lanes policy and with the ethical obligation of authors as researchers, A. Gramenzi, L. Cornegliani and P. Persico declare that they are consultants of the company and declare that they have acted following the recommendations on Good Publication Practices to ensure ethical and transparent editorial practices.

Figures

Figure 1
Figure 1
Study design flow chart.
Figure 2
Figure 2
Statistical results of VAS values calculated for each period. Boxplot of VAS value of 32 dogs at time 0, 30, 60, 90, 120 days. Level of Significance compared to time 0: *** 1%; ** 5%; * 10%.
Figure 3
Figure 3
Statistical results of CADLI values calculated for each period, Boxplot of CADLI value of 32 dogs at time 0, 30, 60, 90, 120 days. Level of Significance compared to time 0: *** 1%; ** 5%; * 10%.
Figure 4
Figure 4
Statistical results of FeSc values calculated for each period. Boxplot of FeSc value of 32 dogs at time 0, 30, 60, 90, 120 days. Level of Significance compared to time 0 and 30 days: *** 1%; ** 5%; * 10%.
Figure 5
Figure 5
Statistical results of dysbiosis index calculated for each period Boxplot of FeSc value of 32 dogs at time 0, 30, 60, 90, 120 days. Level of Significance compared to time 0, 30 and 60 days: *** 1%; ** 5%; * 10%.
See this image and copyright information in PMC

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