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Review
. 2021 Sep 27;11(10):1411.
doi: 10.3390/biom11101411.

A Proteomic View of Cellular and Molecular Effects of Cannabis

Morteza Abyadeh  1 , Vivek Gupta  2 , Joao A Paulo  3 , Veer Gupta  4 , Nitin Chitranshi  2 , Angela Godinez  2 , Danit Saks  2 , Mafruha Hasan  5 , Ardeshir Amirkhani  6 , Matthew McKay  7 , Ghasem H Salekdeh  8 , Paul A Haynes  8 , Stuart L Graham  2 , Mehdi Mirzaei  2
Affiliations
Review

A Proteomic View of Cellular and Molecular Effects of Cannabis

Morteza Abyadeh et al. Biomolecules. .

Abstract

Cannabis (Cannabis sativa), popularly known as marijuana, is the most commonly used psychoactive substance and is considered illicit in most countries worldwide. However, a growing body of research has provided evidence of the therapeutic properties of chemical components of cannabis known as cannabinoids against several diseases including Alzheimer's disease (AD), multiple sclerosis (MS), Parkinson's disease, schizophrenia and glaucoma; these have prompted changes in medicinal cannabis legislation. The relaxation of legal restrictions and increased socio-cultural acceptance has led to its increase in both medicinal and recreational usage. Several biochemically active components of cannabis have a range of effects on the biological system. There is an urgent need for more research to better understand the molecular and biochemical effects of cannabis at a cellular level, to understand fully its implications as a pharmaceutical drug. Proteomics technology is an efficient tool to rigorously elucidate the mechanistic effects of cannabis on the human body in a cell and tissue-specific manner, drawing conclusions associated with its toxicity as well as therapeutic benefits, safety and efficacy profiles. This review provides a comprehensive overview of both in vitro and in vivo proteomic studies involving the cellular and molecular effects of cannabis and cannabis-derived compounds.

Keywords: cannabidiol; cannabinoids; cannabis; marijuana; proteomics; tetrahydrocannabinol.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Various diseases against which cannabis/cannabinoids have potential for prevention and treatment (up and down arrows indicate increase and decrease respectively).
Figure 2
Figure 2
Chemical structures, molecular formula (MF), molecular weight (MW) and the affinity for CB1R and CB2R of the three natural components of cannabis including: Tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabigerol (CBG) and two synthetic cannabinoids known as CP-47,497-C8 and WIN 55,212-2.
Figure 3
Figure 3
Proteomics workflow to identify differentially expressed proteins (DEPs), their function and associated pathways in the brain of mice/rats, following exposure to THC at different life stages.
See this image and copyright information in PMC

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