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Review
. 2021 Oct 10;22(20):10928.
doi: 10.3390/ijms222010928.

Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review)

Aleksey M Chaulin  1   2
Affiliations
Review

Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review)

Aleksey M Chaulin. Int J Mol Sci. .

Abstract

The metabolic processes of endo- and exogenous compounds play an important role in diagnosing and treating patients since many metabolites are laboratory biomarkers and/or targets for therapeutic agents. Cardiac troponins are one of the most critical biomarkers to diagnose cardiovascular diseases, including acute myocardial infarction. The study of troponin metabolism is of great interest as it opens up new possibilities for optimizing laboratory diagnostics. This article discusses in detail the key stages of the cardiac troponins metabolism, in particular the mechanisms of release from a healthy myocardium, mechanisms of circulation in the bloodstream, possible mechanisms of troponin penetration into other biological fluids (oral fluid, cerebrospinal fluid, pericardial and amniotic fluids), mechanisms of elimination of cardiac troponins from the blood, and daily changes in the levels of troponins in the blood. Considering these aspects of cardiac troponin metabolism, attention is focused on the potential value for clinical practice.

Keywords: cardiac troponin; circadian; circulation; diagnostics; elimination of cardiac troponins; mechanisms of troponin release; metabolism.

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Conflict of interest statement

The author declare no conflict of interest.

References

    1. Gomes A.V., Potter J.D., Szczesna-Cordary D. The Role of Troponins in Muscle Contraction. IUBMB Life. 2002;54:323–333. doi: 10.1080/15216540216037. - DOI - PubMed
    1. Chaulin A.M. Elevation Mechanisms and Diagnostic Consideration of Cardiac Troponins under Conditions Not Associated with Myocardial Infarction: Part 1. Life. 2021;11:914. doi: 10.3390/life11090914. - DOI - PMC - PubMed
    1. Duplyakov D.V., Chaulin A.M. Mutations of heart troponines, associated with cardiomyopathies. Kardiologiya. 2019;7:8–17. doi: 10.24411/2309-1908-2019-13001. (In Russian) - DOI
    1. Tadros H., Life C.S., Garcia G., Pirozzi E., Jones E.G., Datta S., Parvatiyar M.S., Chase P.B., Allen H.D., Kim J.J., et al. Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes. J. Mol. Cell. Cardiol. 2020;142:118–125. doi: 10.1016/j.yjmcc.2020.04.005. - DOI - PMC - PubMed
    1. Thygesen K., Alpert J.S., Jaffe A.S., Chaitman B.R., Bax J.J., Morrow D.A., White H.D., The Executive Group on behalf of the Joint European Society of Cardiology (ESC) American College of Cardiology (ACC) American Heart Association (AHA) et al. Task Force for the Universal Definition of Myocardial Infarction Fourth Universal Definition of Myocardial Infarction (2018) Circulation. 2018;138:e618–e651. doi: 10.1161/CIR.0000000000000617. - DOI - PubMed

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