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Review
. 2021 Oct 9;10(20):4631.
doi: 10.3390/jcm10204631.

Infantile Hemangiomas: An Update on Pathogenesis and Treatment

Małgorzata Kowalska  1 , Wojciech Dębek  1 , Ewa Matuszczak  1
Affiliations
Review

Infantile Hemangiomas: An Update on Pathogenesis and Treatment

Małgorzata Kowalska et al. J Clin Med. .

Abstract

Infantile hemangiomas are the most common benign vascular tumors in infancy. This review includes an update on the current knowledge on pathogenesis, a discussion on indications for treatment, and a review of the mechanisms underlying the different treatment methods. Although most infantile hemangiomas require only active observation because of their natural course, which results in involution, about 10% present with complications that require immediate treatment. The basic treatment includes systemic and topical options. In cases of insufficient response or rebound growth, other forms of treatment should be considered. In some cases, combined therapy might be initiated.

Keywords: PDL; infantile hemangioma; propranolol.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Characteristics of infantile hemangiomas with a high risk of complications.
Figure 2
Figure 2
Treatment indications considering size, depth, and the morphological character of infantile hemangiomas.
See this image and copyright information in PMC

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References

    1. Léauté-Labrèze C., Harper J.I., Hoeger P.H. Infantile haemangioma. Lancet. 2017;390:85–94. doi: 10.1016/S0140-6736(16)00645-0. - DOI - PubMed
    1. Oksiuta M., Matuszczak E., Debek W., Dzienis-Koronkiewicz E., Hermanowicz A. Treatment of rapidly proliferating haemangiomas in newborns with propranolol and review of the literature. J. Matern. Neonatal Med. 2014;29:64–68. doi: 10.3109/14767058.2014.986650. - DOI - PubMed
    1. Ding Y., Zhang J.-Z., Yu S.-R., Xiang F., Kang X.-J. Risk factors for infantile hemangioma: A meta-analysis. World J. Pediatr. 2019;16:377–384. doi: 10.1007/s12519-019-00327-2. - DOI - PubMed
    1. Drolet B.A., Swanson E.A., Frieden I. Infantile Hemangiomas: An Emerging Health Issue Linked to an Increased Rate of Low Birth Weight Infants. J. Pediatr. 2008;153:712-715.e1. doi: 10.1016/j.jpeds.2008.05.043. - DOI - PubMed
    1. ISSVA Classification of Vascular Anomalies ©2018 International Society for the Study of Vascular Anomalies. [(accessed on 31 October 2020)]. Available online: issva.org/classification.

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