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Review
. 2021 Oct 12;10(20):4665.
doi: 10.3390/jcm10204665.

Hodgkin Lymphoma: A Special Microenvironment

Giuseppina Opinto  1 , Claudio Agostinelli  2   3 , Sabino Ciavarella  1 , Attilio Guarini  1 , Eugenio Maiorano  4 , Giuseppe Ingravallo  4
Affiliations
Review

Hodgkin Lymphoma: A Special Microenvironment

Giuseppina Opinto et al. J Clin Med. .

Abstract

Classical Hodgkin's lymphoma (cHL) is one of the most particular lymphomas for the few tumor cells surrounded by an inflammatory microenvironment. Reed-Sternberg (RS) and Hodgkin (H) cells reprogram and evade antitumor mechanisms of the normal cells present in the microenvironment. The cells of microenvironment are essential for growth and survival of the RS/H cells and are recruited through the effect of cytokines/chemokines. We summarize recent advances in gene expression profiling (GEP) analysis applied to study microenvironment component in cHL. We also describe the main therapies that target not only the neoplastic cells but also the cellular components of the background.

Keywords: Classical Hodgkin’s lymphoma; gene expression profiling; microenvironment; therapy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 2
Figure 2
Published studies examining GEP and outcome in classical Hodgkin lymphoma.
Figure 1
Figure 1
(A) Representative figure of Hodgkin Lymphoma (40X, Hematoxylin Eosin). (B) Cartoon of Hodgkin Lymphoma, few RS and H cells (1–10%) immerse in a special microenvironment. The 90% of the tumor mass is composed by CD4+ Th cells, CD4+ Tregs, CD8 T cells, B lymphocytes, plasma cells, histiocytes/macrophages, granulocytes, eosinophils, mast cells, MSCs and endothelial cells.
See this image and copyright information in PMC

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