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Review
. 2021 Oct 16;10(20):4750.
doi: 10.3390/jcm10204750.

The Role of Uric Acid in Acute and Chronic Coronary Syndromes

Alessandro Maloberti  1   2 , Marco Biolcati  1   2 , Giacomo Ruzzenenti  1   2 , Valentina Giani  1   2 , Filippo Leidi  1   2 , Massimiliano Monticelli  1   2 , Michela Algeri  2 , Sara Scarpellini  2 , Stefano Nava  3 , Francesco Soriano  3 , Jacopo Oreglia  3 , Alice Sacco  3 , Nuccia Morici  3 , Fabrizio Oliva  3 , Federica Piani  4 , Claudio Borghi  4 , Cristina Giannattasio  1   2
Affiliations
Review

The Role of Uric Acid in Acute and Chronic Coronary Syndromes

Alessandro Maloberti et al. J Clin Med. .

Abstract

Uric acid (UA) is the final product of the catabolism of endogenous and exogenous purine nucleotides. While its association with articular gout and kidney disease has been known for a long time, new data have demonstrated that UA is also related to cardiovascular (CV) diseases. UA has been identified as a significant determinant of many different outcomes, such as all-cause and CV mortality, and also of CV events (mainly Acute Coronary Syndromes (ACS) and even strokes). Furthermore, UA has been related to the development of Heart Failure, and to a higher mortality in decompensated patients, as well as to the onset of atrial fibrillation. After a brief introduction on the general role of UA in CV disorders, this review will be focused on UA's relationship with CV outcomes, as well as on the specific features of patients with ACS and Chronic Coronary Syndrome. Finally, two issues which remain open will be discussed: the first is about the identification of a CV UA cut-off value, while the second concerns the possibility that the pharmacological reduction of UA is able to lower the incidence of CV events.

Keywords: acute coronary syndrome; chronic coronary syndrome; uric acid.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Mechanisms contributing to the relationship between uric acid and cardiovascular diseases. HTN = Arterial Hypertension; DM = Diabetes Mellitus; CKD = Chronic Kidney Disease; TOD = Target Organ Damage.
Figure 2
Figure 2
Summary of the different uric acid cut-offs according to cardiovascular diseases. CV = Cardiovascular; MI = Myocardial Infarction; HF = Heart Failure.
See this image and copyright information in PMC

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