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. 2021 Oct 4;9(10):2096.
doi: 10.3390/microorganisms9102096.

Virucidal Effect of the Mesoscopic Structure of CAC-717 on Severe Acute Respiratory Syndrome Coronavirus-2

Takashi Yokoyama  1   2 , Tomoyasu Nishimura  2 , Yoshifumi Uwamino  2 , Kenjiro Kosaki  3 , Koichi Furusaki  4 , Rumiko Onishi  5 , Takashi Onodera  1 , Makoto Haritani  1   6 , Katsuaki Sugiura  1   7 , Rikio Kirisawa  8 , Naoki Hasegawa  2
Affiliations

Virucidal Effect of the Mesoscopic Structure of CAC-717 on Severe Acute Respiratory Syndrome Coronavirus-2

Takashi Yokoyama et al. Microorganisms. .

Abstract

Here, the virucidal effect of calcium bicarbonate with a mesoscopic structure (CAC-717) on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was determined. Assays showed that CAC-717 had a strong virucidal effect on all examined SARS-CoV-2 isolates, including variant strains. The viral infectivity decreased within 15 s, and the virucidal activity of CAC-717 at a 1:49 ratio was similar to that of ethanol disinfectant. CAC-717 neutralization eliminated this virucidal effect, indicating that the alkaline condition of CAC-717 is important for virus inactivation and is an indicator of its mesoscopic structure and virucidal activity. The virucidal effect was observed in the presence of organic matter (bovine serum albumin). CAC-717 is a non-invasive and non-flammable substance with a low environmental burden, and its usefulness as a novel disinfectant has been confirmed.

Keywords: CAC-717; SARS-CoV-2; disinfectant; mesoscopic structure.

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Conflict of interest statement

Santa Mineral Co., Ltd. supports the endowed laboratory of Environmental Science for Sustainable Development, Tokyo University (T.Y., T.O., M.H. and K.S.). Orix conducts joint business with Santa Mineral and supports the Department of Infectious Diseases, Keio University School of Medicine (T.Y., T.N., Y.U. and N.H.). The Mineral Activation Technical Research Center is supported by Santa Mineral Co., Ltd. (K.F.). RO presides over Santa Mineral Co., Ltd. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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