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. 2021 Sep 22;57(10):997.
doi: 10.3390/medicina57100997.

Pathophysiology of Vaccine-Induced Prothrombotic Immune Thrombocytopenia (VIPIT) and Vaccine-Induced Thrombocytopenic Thrombosis (VITT) and Their Diagnostic Approach in Emergency

Pierpaolo Di Micco  1 , Giuseppe Camporese  2 , Giuseppe Cardillo  3 , Corrado Lodigiani  4 , Novella Carannante  5 , Anna Annunziata  6 , Giuseppe Fiorentino  6 , Vincenzo Russo  7 , Egidio Imbalzano  8
Affiliations

Pathophysiology of Vaccine-Induced Prothrombotic Immune Thrombocytopenia (VIPIT) and Vaccine-Induced Thrombocytopenic Thrombosis (VITT) and Their Diagnostic Approach in Emergency

Pierpaolo Di Micco et al. Medicina (Kaunas). .

Abstract

SARS-CoV-2 induced a pandemic that is reported to have started in Asia and was then extended to other countries in the world. Main clinical aspects of this viral infection have been lung injuries with severe pneumonia requiring prolonged hospitalization and associated morbidities such as venous thromboembolism and/or superinfection by bacteria, fungus or other pests. Immediately there was a need to develop a sustainable therapeutic strategy, such as vaccination. Vaccines against Covid-19, in fact, exert a protective action for common people and reduce viral diffusion. Yet, vaccination of a large number of people raises the question of a well-known complication of several types of vaccines; this complication is immune thrombocytopenia, which is sometimes associated with thrombosis as well. In this short review, we summarized mechanisms involved in the pathogenesis of vaccine-induced prothrombotic immune thrombocytopenia and vaccine-induced thrombocytopenic thrombosis.

Keywords: COVID-19; SARS-CoV-2; anti-SARS-CoV-2 vaccine; pandemic; vaccine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart to manage patients with suspected VIPIT\VITT at the emergency room.
See this image and copyright information in PMC

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