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. 1986 Dec 22;14(24):9653-66.
doi: 10.1093/nar/14.24.9653.

Transcriptional and post-transcriptional regulation of c-myc expression during the differentiation of murine erythroleukemia Friend cells

N Mechti, M Piechaczyk, J M Blanchard, L Marty, A Bonnieu, P Jeanteur, B Lebleu
Free PMC article

Transcriptional and post-transcriptional regulation of c-myc expression during the differentiation of murine erythroleukemia Friend cells

N Mechti et al. Nucleic Acids Res. .
Free PMC article

Abstract

c-myc RNA rapidly decreases to barely detectable levels in Friend erythroleukemia cells induced to differentiate upon the addition of dimethylsulfoxide. We show here that c-myc gene is down-regulated both at the transcriptional level presumably by a block in the elongation of primary transcripts and at the post-transcriptional level by an increase in the degradation of its mRNA.

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