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. 2021 Sep 24;11(10):2492.
doi: 10.3390/nano11102492.

Sucrose-Responsive Intercommunicated Janus Nanoparticles Network

Sandra Jimenez-Falcao  1 , Daniel Torres  1 , Paloma Martínez-Ruiz  1 , Diana Vilela  1 , Ramón Martínez-Máñez  2   3   4 , Reynaldo Villalonga  1
Affiliations

Sucrose-Responsive Intercommunicated Janus Nanoparticles Network

Sandra Jimenez-Falcao et al. Nanomaterials (Basel). .

Abstract

Inspired by biological systems, the development of artificial nanoscale materials that communicate over a short distance is still at its early stages. This work shows a new example of a cooperating system with intercommunicated devices at the nanoscale. The system is based on the new sucrose-responsive Janus gold-mesoporous silica (Janus Au-MS) nanoparticles network with two enzyme-powered nanodevices. These nanodevices involve two enzymatic processes based on invertase and glucose oxidase, which are anchored on the Au surfaces of different Janus Au-MS nanoparticles, and N-acetyl-L-cysteine and [Ru(bpy)3]2+ loaded as chemical messengers, respectively. Sucrose acts as the INPUT, triggering the sequential delivery of two different cargoes through the enzymatic control. Nanoscale communication using abiotic nanodevices is a developing potential research field and may prompt several applications in different disciplines, such as nanomedicine.

Keywords: Janus particles; enzymatic control; intercommunication; nanodevices; network.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
Schematic representation of the performance of the intercommunicated Janus nanoparticle network (J1c and J2c) in presence of sucrose.
Figure 1
Figure 1
Characterization of the J1c nanodevice: (A) HR-TEM image of J. (B) Infrared spectra and (C) thermograms for the Janus Au-MS nanoparticles J, J1a, and J1b. (D) N2 adsorption-desorption isotherms for J, J1a, and J1b (Inset: pore size distribution). (E) Hydrodynamic diameter and (F) Zeta potential of J, J1a, and J1b.
Figure 2
Figure 2
Characterization of the J2c nanodevice: (A) HR-TEM image of J. (B) infrared spectra and (C) thermograms for the Janus Au-MS nanoparticles J, J2a, and J2b. (D) N2 adsorption-desorption isotherms for J, J2a, and J2b (Inset: pore size distribution). (E) Hydrodynamic diameter and (F) Zeta potential of J, J2a, and J2b.
Figure 3
Figure 3
Cargo release assays control assays: (A) Kinetics of [Ru(bpy)3]2+ release encapsulated in J1b in the presence of 50 mM N-acetyl-L-cysteine. (B) Kinetics of [Ru(bpy)3]2+ release encapsulated in J1b in the presence of J2b and the addition of acid media. (Conditions: 20 mM Na2SO4, pH 7.5, 25 °C, [J1b] = 3 mg mL−1, [J2b] = 3 mg mL−1, λabs = 454 nm). Error bars correspond to the s.d. from three independent experiments.
Figure 4
Figure 4
Sucrose-responsive interaction between Janus nanoparticles: (A) % of [Ru(bpy)3]2+ release encapsulated in J1c because of the interaction between Jc1c and Jc2c after 100 min of sucrose (50 mM) addition. (B) Kinetics of [Ru(bpy)3]2+ release encapsulated in J1c for different proportions of J2c in the presence of 50 mM of sucrose. (C) Kinetics of [Ru(bpy)3]2+ release encapsulated in J1c because of the interaction between J1c and J2c after the addition of 50 mM of sucrose. (D) % of [Ru(bpy)3]2+ release encapsulated in Jc1c because of the interaction between J1c and J2c at different sucrose concentrations (t = 6h). (Conditions: 20 mM Na2SO4, pH 7.5, 25 °C, [J1b] = 3 mg mL−1, [J2b] = 3 mg mL−1, λabs = 454 nm). Error bars correspond to the s.d. from three independent experiments.
Figure 5
Figure 5
Effect of the presence of different sugars to the communication system’s established chemical response. (Conditions: 20 mM Na2SO4, pH 7.5, 25 °C, [J1c] = 3 mg mL−1, [J2c] = 3 mg mL−1, λabs = 454 nm). Error bars correspond to the s.d. from three independent experiments.
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