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Review
. 2022 Jan;8(1):4-8.
doi: 10.1016/j.trecan.2021.09.005. Epub 2021 Oct 20.

ERAP1 as an emerging therapeutic target for medulloblastoma

Francesca Bufalieri  1 , Doriana Fruci  2 , Lucia Di Marcotullio  3
Affiliations
Review

ERAP1 as an emerging therapeutic target for medulloblastoma

Francesca Bufalieri et al. Trends Cancer. 2022 Jan.

Abstract

Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme that shapes the peptide repertoire presented by major histocompatibility complex class I (MHC-I) molecules, thereby affecting tumor immunogenicity. ERAP1 is altered in many tumors, including medulloblastoma (MB). We review the role of ERAP1 in MB development and the possibility of targeting this enzyme for MB treatment.

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Declaration of interests No interests are declared.

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