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Editorial
. 2022 Feb 10;43(6):534-537.
doi: 10.1093/eurheartj/ehab723.

The promise of the gut metabolite propionate for a novel and personalized lipid-lowering treatment

Elena Osto  1
Affiliations
Editorial

The promise of the gut metabolite propionate for a novel and personalized lipid-lowering treatment

Elena Osto. Eur Heart J. .
No abstract available

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Figures

Graphical Abstract
Graphical Abstract
Novel insights and open questions about the anti-atherosclerotic actions of propionate through immune-dependent regulation of intestinal cholesterol metabolism; adapted from Haghikia et al.
See this image and copyright information in PMC

Comment on

  • Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.
    Haghikia A, Zimmermann F, Schumann P, Jasina A, Roessler J, Schmidt D, Heinze P, Kaisler J, Nageswaran V, Aigner A, Ceglarek U, Cineus R, Hegazy AN, van der Vorst EPC, Döring Y, Strauch CM, Nemet I, Tremaroli V, Dwibedi C, Kränkel N, Leistner DM, Heimesaat MM, Bereswill S, Rauch G, Seeland U, Soehnlein O, Müller DN, Gold R, Bäckhed F, Hazen SL, Haghikia A, Landmesser U. Haghikia A, et al. Eur Heart J. 2022 Feb 10;43(6):518-533. doi: 10.1093/eurheartj/ehab644. Eur Heart J. 2022. PMID: 34597388 Free PMC article. Clinical Trial.

References

    1. Timmis A, Townsend N, Gale CP, Torbica A, Lettino M, Petersen SE, Mossialos EA, Maggioni AP, Kazakiewicz D, May HT, De Smedt D, Flather M, Zuhlke L, Beltrame JF, Huculeci R, Tavazzi L, Hindricks G, Bax J, Casadei B, Achenbach S, Wright L, Vardas P; European Society of Cardiology. European Society of Cardiology: Cardiovascular Disease Statistics 2019. Eur Heart J 2020;41:12–85. - PubMed
    1. Schupack DA, Mars RAT, Voelker DH, Abeykoon JP, Kashyap PC. The promise of the gut microbiome as part of individualized treatment strategies. Nat Rev Gastroenterol Hepatol 2021; doi: 10.1038/s41575-021-00499-1. - DOI - PMC - PubMed
    1. Fan Y, Pedersen O. Gut microbiota in human metabolic health and disease. Nat Rev Microbiol 2021;19:55–71. - PubMed
    1. Nogal A, Valdes AM, Menni C. The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health. Gut Microbes 2021;13:1–24. - PMC - PubMed
    1. Wang DD, Nguyen LH, Li Y, Yan Y, Ma W, Rinott E, Ivey KL, Shai I, Willett WC, Hu FB, Rimm EB, Stampfer MJ, Chan AT, Huttenhower C. The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk. Nat Med 2021;27:333–343. - PMC - PubMed