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Review
. 2022 May;279(5):2239-2244.
doi: 10.1007/s00405-021-07136-2. Epub 2021 Oct 23.

Ramsay Hunt syndrome with multiple cranial neuropathy: a literature review

Saikrishna Ananthapadmanabhan  1 , Dilshard Soodin  2 , Niranjan Sritharan  2   3 , Vanaja Sivapathasingam  2
Affiliations
Review

Ramsay Hunt syndrome with multiple cranial neuropathy: a literature review

Saikrishna Ananthapadmanabhan et al. Eur Arch Otorhinolaryngol. 2022 May.

Abstract

Background: Ramsay Hunt Syndrome (RHS) is a neurotological disorder involving the reactivation of the varicella-zoster virus (VZV) in the geniculate ganglion of the facial nerve (Sweeney and Gilden in J Neurol Neurosurg Psychiatry 71:149-154, 2001). The characteristic presentation involves ipsilateral lower motor neuron type facial paresis, auricular pain with or without hearing impairment, and vesicular lesions of the external auditory canal and outer ear. Involvement of the facial and vestibulocochlear nerve is typical in RHS, whilst multiple cranial neuropathies are rare and associated with poorer prognosis and systemic complications (Arya et al. in Am J Case Rep 19:68-71, 2017; Shinha and Krishna in IDCases 2:47-48, 2015; Shim et al. in Acta Otolaryngol 131:210-215, 2011; Coleman et al. in J Voice 26:e27-e28, 2012; Morelli et al. in Neurol Sci 29:497-498, 2008;). Likely mechanisms involved in the pathogenesis of cranial polyneuropathy include direct peri-neural and trans-axonal spread of viral inflammation between contiguous cranial nerves and haematogenous dissemination between nerves with shared blood supply. Impairments in speech, swallowing, hearing, and oculo-protection can contribute to morbidity and requires a multidisciplinary approach to patient care.

Methods: We present a rare case of RHS with multiple cranial neuropathies followed by a comprehensive review of current literature with regard to the pathophysiology, diagnostic workup, and the management strategies employed in these patients.

Conclusion: RHSs with multiple cranial neuropathies are important to recognise as they are associated with significant morbidity and poor prognosis. A multidisciplinary approach to patient management is required to address the several complications that can arise from cranial nerve deficits, especially in regard to speech and swallow.

Keywords: Dysphagia; Facial nerve; Herpes zoster oticus; Polyneuropathy; Ramsay Hunt syndrome; Varicella-zoster.

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References

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    1. Shinha T, Krishna P (2015) Ramsay Hunt syndrome and zoster laryngitis with multiple cranial nerve involvement. IDCases 2(2):47–48. https://doi.org/10.1016/j.idcr.2015.02.003 - PubMed - PMC - DOI
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    1. Coleman C, Fozo M, Rubin A (2012) Ramsay Hunt syndrome with severe dysphagia. J Voice 26(1):e27–e28 - PubMed - DOI

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