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Editorial
. 2021 Oct 8:12:778880.
doi: 10.3389/fphar.2021.778880. eCollection 2021.

Editorial: Verification of Animal Pain Models by Reverse Translation

Robert M Caudle  1 , Maree Therese Smith  2 , E Alfonso Romero-Sandoval  3
Affiliations
Editorial

Editorial: Verification of Animal Pain Models by Reverse Translation

Robert M Caudle et al. Front Pharmacol. .
No abstract available

Keywords: analgesic; animal models; bedside to bench; behavioral testing; nociception.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Modeling human pain disorders in animals. Rodent injury models have been the standard for pain research and therapy evaluation. These models need to be compared to the human disease they model to ensure that they are predictive. The mechanism based rodent models are theoretically superior to the injury models due to their focus on specific mechanisms for producing pain. These models are developed based on known or suspected causes of the human disease. The companion animal models are most closely related to human disease and can bridge the gap between rodent studies and humans. If possible, it is recommended that companion animal clinical trials be conducted after the rodent studies and prior to initiating human trials.
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  • Editorial on the Research TopicVerification of Animal Pain Models by Reverse Translation

References

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