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. 2021;2021(1):468.
doi: 10.1186/s13662-021-03618-z. Epub 2021 Oct 20.

Modeling the transmission dynamics of delayed pneumonia-like diseases with a sensitivity of parameters

Affiliations

Modeling the transmission dynamics of delayed pneumonia-like diseases with a sensitivity of parameters

Muhammad Naveed et al. Adv Differ Equ. 2021.

Abstract

Pneumonia is a highly transmitted disease in children. According to the World Health Organization (WHO), the most affected regions include South Asia and sub-Saharan Africa. 15% deaths of children are due to pneumonia. In 2017, 0.88 million children were killed under the age of five years. An analysis of pneumonia disease is performed with the help of a delayed mathematical modelling technique. The epidemiological system contemplates subpopulations of susceptible, carriers, infected and recovered individuals, along with nonlinear interactions between the members of those subpopulations. The positivity and the boundedness of the ongoing problem for nonnegative initial data are thoroughly proved. The system possesses pneumonia-free and pneumonia existing equilibrium points, whose stability is studied rigorously. Moreover, the numerical simulations confirm the validity of these theoretical results.

Keywords: Delayed model; Numerical simulations; Pneumonia disease; Stability analysis.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Flow chart of the pneumonia disease model
Figure 2
Figure 2
Subpopulations plots concerning the time of system (1)–(4) at the pneumonia-free equilibrium of the model when τ=0
Figure 3
Figure 3
Time plots at the pneumonia existing equilibrium when τ=0
Figure 4
Figure 4
Subpopulations plots concerning the time of the system at the pneumonia existing equilibrium with practical uses of different values of delay tactics like τ=0.1,0.2,0.5,1 respectively
Figure 5
Figure 5
Simulation of the reproduction number with different values of the delay parameter
Figure 6
Figure 6
Subpopulation of the infected class concerning time with different delay values
Figure 7
Figure 7
Time plots of the system in two-dimensional way when τ=0
Figure 8
Figure 8
Time plots of the system in two-dimensional way when τ=1

References

    1. Mochan E., Swigon D., Ermentrout G., Luken S., Clermont G.A. Mathematical model of intrahost pneumococcal pneumonia infection dynamics in murine strains. J. Theor. Biol. 2014;353:44–54. doi: 10.1016/j.jtbi.2014.02.021. - DOI - PMC - PubMed
    1. Drusano G.L., Liu W., Fikes S., Cirz R., Robbins N., Kurhanewicz S., Louie A. Interaction of drug-and granulocyte-mediated killing of pseudomonas aeruginosa in a murine pneumonia model. J. Infect. Dis. 2014;210(8):1319–1324. doi: 10.1093/infdis/jiu237. - DOI - PMC - PubMed
    1. Ndelwa E.J., Kgosimore M., Massawe E.S., Namkinga L. Mathematical modelling and analysis of treatment and screening of pneumonia. Math. Theory Model. 2015;5(10):21–39.
    1. Kosasih K., Abeyratne U.R., Swarnkar V., Triasih R. Wavelet augmented cough analysis for rapid childhood pneumonia diagnosis. IEEE Trans. Biomed. Eng. 2015;62(4):1185–1194. doi: 10.1109/TBME.2014.2381214. - DOI - PubMed
    1. César A.C.G., Nascimento L.F.C., Mantovani K.C.C., Vieira L.C.P. Fine particulate matter estimated by mathematical model and hospitalisations for pneumonia and asthma in children. Rev. Paul. Pediatr. (Engl. Ed.) 2016;34(1):18–23. doi: 10.1016/j.rpped.2015.06.009. - DOI - PMC - PubMed

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