Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2021 Oct 15:2021:9603660.
doi: 10.1155/2021/9603660. eCollection 2021.

Association between Congenital Cytomegalovirus Infection and Brain Injury in Neonates: A Meta-analysis of Cohort Studies

Li Zhang  1 , Zhankui Li  1 , Xiang Han  2 , Hongyan Du  3 , Yingli Cao  2 , Yingmei Liu  4 , Wenfeng Wang  5   6   7   8
Affiliations
Meta-Analysis

Association between Congenital Cytomegalovirus Infection and Brain Injury in Neonates: A Meta-analysis of Cohort Studies

Li Zhang et al. Behav Neurol. .

Abstract

Objective: To assess association between congenital cytomegalovirus (CMV) infection and brain injury in neonates.

Methods: The literatures from inception to November 4, 2020, were searched through PubMed, Embase, Cochrane Library, and Web of Science. Heterogeneity test was conducted for each indicator and measured by I 2 statistics. If I 2 ≥ 50%, the random effects model was applied; otherwise, the fixed effects model was used. Sensitivity analysis was performed for all models. Weighed mean difference (WMD) was used as the effect size for measurement data, and risk ratio (RR) was as the effect indicator.

Results: A total of 13 studies, including 4,262 congenital CMV infection neonates, were enrolled in this study. Our results showed that the rate of hearing impairment (RR: 2.105, 95% CI: (1.115, 3.971), P = 0.002), sensorineural hearing loss (SNHL) (RR: 17.051, 95% CI: (6.201, 46.886), P < 0.001), and microcephaly (RR: 2.283, 95% CI: (1.325, 3.935), P =0.003) in neonates infected congenital CMV was higher than that in control group.

Conclusion: The risks of hearing impairment, SNHL, and microcephaly in neonates during childhood may be associated with congenital CMV infection. It is necessary to establish neonatal screening programs and comprehensive diagnostic tests for patients to reduce the risk of adverse brain damage to the congenital CMV infection as early as possible and to improve the prognosis of the newborn.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
The flow chart of literature search.
Figure 2
Figure 2
The forest plots of hearing impairment between CMV group and control group.
Figure 3
Figure 3
The forest plots of SNHL between CMV group and control group.
Figure 4
Figure 4
The forest plots of microcephaly between CMV group and control group.
Figure 5
Figure 5
The forest plots of neurodevelopmental delay between CMV group and control group.
Figure 6
Figure 6
The forest plots of MDI between CMV and control groups.
Figure 7
Figure 7
The forest plots of PDI between CMV group and control group.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Hassan J., Connell J. Translational mini-review series on infectious disease: congenital cytomegalovirus infection: 50 years on. Clinical and Experimental Immunology . 2007;149(2):205–210. doi: 10.1111/j.1365-2249.2007.03454.x. - DOI - PMC - PubMed
    1. Kenneson A., Cannon M. J. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Reviews in Medical Virology . 2007;17(4):253–276. doi: 10.1002/rmv.535. - DOI - PubMed
    1. Naing Z. W., Scott G. M., Shand A., et al. Congenital cytomegalovirus infection in pregnancy: a review of prevalence, clinical features, diagnosis and prevention. The Australian & New Zealand Journal of Obstetrics & Gynaecology . 2016;56(1):9–18. doi: 10.1111/ajo.12408. - DOI - PubMed
    1. Dreher A. M., Arora N., Fowler K. B., et al. Spectrum of disease and outcome in children with symptomatic congenital cytomegalovirus infection. The Journal of Pediatrics . 2014;164(4):855–859. doi: 10.1016/j.jpeds.2013.12.007. - DOI - PMC - PubMed
    1. Zhang X. W., Li F., Yu X. W., Shi X. W., Shi J., Zhang J. P. Physical and intellectual development in children with asymptomatic congenital cytomegalovirus infection: a longitudinal cohort study in Qinba mountain area, China. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology . 2007;40(3):180–185. doi: 10.1016/j.jcv.2007.08.018. - DOI - PubMed

Publication types

MeSH terms