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Case Reports
. 2021 Oct 13;9(10):e04966.
doi: 10.1002/ccr3.4966. eCollection 2021 Oct.

Clinico-pathological profiling of peripheral ossifying fibroma of the oral cavity

Ashish Shrestha  1 , Shashi Keshwar  1 , Neetu Jain  1 , Toniya Raut  1 , Mehul Rajesh Jaisani  2 , Shiva Lal Sharma  3
Affiliations
Case Reports

Clinico-pathological profiling of peripheral ossifying fibroma of the oral cavity

Ashish Shrestha et al. Clin Case Rep. .

Abstract

POF represents a separate entity with diverse histological presentation. Considerable overlapping of clinical and histological features are present among different reactive gingival lesions, which warrant a meticulous review for the diagnosis of POF.

Keywords: Calcification; Histopathology; Peripheral ossifying fibroma.

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Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
Histopathological features with varying mesenchymal presentations of peripheral ossifying fibroma exhibiting; active fibroblast (A); fasciculate pattern (B); dystrophic calcification in primitive mesenchyme‐like background (C); interconnecting trabecular pattern of lamellar bone with loosely cellular surrounding areas (D; 10×, H&E)
FIGURE 2
FIGURE 2
Histopathological features of peripheral ossifying fibroma exhibiting; woven bone and cementum‐like materials (A, 10×); hyalinized eosinophilic area in attempt of bone formation (B, 10×); extended bone formation approaching atrophic epithelium (C, 10×); brush border pattern (D, 40×; H&E)
FIGURE 3
FIGURE 3
Diverse histopathological presentation with; perivascular calcification (A, 40×) and hyalinization (B, 10×); Three distinct zones from epithelium till deeper layers of connective tissue in peripheral ossifying fibroma (C, 4×; H&E)
See this image and copyright information in PMC

References

    1. Kumar S, Ram S, Jorgensen M, Shuler C, Sedghizadeh P. Multicentric peripheral ossifying fibroma. J Oral Sci. 2006;48(4):239‐243. - PubMed
    1. Hunasgi S, Koneru A, Vanishree M, Manvikar V. Assessment of reactive gingival lesions of oral cavity: a histopathological study. J Oral Maxillofac Pathol. 2017;21(1):180. 10.4103/jomfp.JOMFP - DOI - PMC - PubMed
    1. Chandwani M, Fernandes G. Peripheral ossifying fibroma: review and case report. Biomed Res Clin Pract. 2018;3(3):1‐4. 10.15761/brcp.1000168 - DOI
    1. Shepherd S. Alveolar exostosis. Am J Dent Sc. 1844;4:43‐44. - PMC - PubMed
    1. Gnepp D. Diagnostic Surgical Pathology of the Head and Neck. 2nd Edn. Saunders Elsevier. In: Elsevier, ed. 2nd ed.; 2009:211‐214.

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