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. 2021 Sep 4;11(4):e117140.
doi: 10.5812/aapm.117140. eCollection 2021 Aug.

Evaluation of the Effect of Atorvastatin Administration on the Outcomes of Patients with Traumatic Brain Injury: A Double-blinded Randomized Clinical Trial

Farhad Soltani  1 , Farahzad Janatmakan  1 , Sara Jorairahmadi  1 , Fatemeh Javaherforooshzadeh  1 , Pooyan Alizadeh  1 , Ismail Alipour  1
Affiliations

Evaluation of the Effect of Atorvastatin Administration on the Outcomes of Patients with Traumatic Brain Injury: A Double-blinded Randomized Clinical Trial

Farhad Soltani et al. Anesth Pain Med. .

Abstract

Background: Traumatic brain injury (TBI) is one of the common causes of long-term disabilities and mortality. This study aimed to evaluate the effect of atorvastatin administration on the Glasgow Coma Scale (GCS), Glasgow Outcome Scale (GOS), and Disability Rating Scale (DRS) in patients with TBI.

Methods: This double-blinded randomized clinical trial included 60 patients with TBI in Golestan Hospital of Ahvaz, Iran. After obtaining an informed consent from all patients, the patients were randomly assigned into two groups. For the intervention group, atorvastatin with a daily dose of 20 mg was used. The control group was administered the same amount of placebo for 10 days. Changes in the level of consciousness were measured using the GCS, and functional recovery rate in patients was measured by GOS and DRS in the third follow-up month.

Results: According to the obtained results, compared with the control group, the atorvastatin administration significantly increased the level of GCS and DRS within 2 - 3 months post-intervention and improved GOS since the tenth day after the study (P < 0.05).

Conclusions: The results revealed the positive effect of atorvastatin on the improvement of outcomes measurements such as GCS, DRS, and GOS in patients after moderate and severe TBI.

Keywords: Atorvastatin; Glasgow Coma Scale (GCS); Glasgow Outcome Scale (GOS); Traumatic Brain Injury (TBI).

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Conflict of interest statement

Conflict of Interests: There was no conflict of interest to be declared.

Figures

Figure 1.
Figure 1.. Seventy subjects were registered in the study, of whom 60 met the inclusion criteria and consented to participate. Patients were divided into two groups (n = 30 in each).
See this image and copyright information in PMC

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