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Case Reports
. 2021 Aug 28;11(4):e117808.
doi: 10.5812/aapm.117808. eCollection 2021 Aug.

Massive Pulmonary Emboli in Klinefelter Syndrome: A Rare Case Report

Fatemeh Javaherforooshzadeh  1 , Yusef Torfi  2
Affiliations
Case Reports

Massive Pulmonary Emboli in Klinefelter Syndrome: A Rare Case Report

Fatemeh Javaherforooshzadeh et al. Anesth Pain Med. .

Abstract

Introduction: Klinefelter syndrome (KS) is a genetic disorder that affects men. An augmented incidence of the thromboembolic event described in patients with KS.

Case presentation: A 34-year-old male identified with a definitive diagnosis of KS was hospitalized to our cardiac surgery center through the emergency with chief complaints of acute chest pain and dyspnea. Saddle pulmonary thromboembolism was established from chest Computed Tomography Angiography (CTA). The patient's symptoms resolved after embolectomy via surgery.

Conclusions: There is a tendency for hypercoagulability in KS. This tendency is because of hormonal discrepancy and hereditary thrombophilic factors. So, patients with KS and past medical history of venous thromboembolism necessitate constant oral anticoagulation therapy.

Keywords: Embolectomy; Klinefelter Syndrome; Saddle Pulmonary Embolism.

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Conflict of interest statement

Conflict of Interests: There was no conflict of interest to be declared.

Figures

Figure 1.
Figure 1.. Thromboembolic material got by pulmonary endarterectomy in the main pulmonary artery as well as in the right and left main branches.
See this image and copyright information in PMC

References

    1. Rajpurkar M, Biss T, Amankwah EK, Martinez D, Williams S, Van Ommen CH, et al. Pulmonary embolism and in situ pulmonary artery thrombosis in paediatrics. A systematic review. Thromb Haemost. 2017;117(6):1199–207. doi: 10.1160/TH16-07-0529. - DOI - PubMed
    1. Konstantinides SV, Torbicki A, Agnelli G, Danchin N, Fitzmaurice D, Galie N, et al. 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism: The task force for the diagnosis and management of acute pulmonary embolism of the European society of cardiology (ESC. Eur Heart J. 2014;35(43):3033–3080. doi: 10.1093/eurheartj/ehu283. - DOI - PubMed
    1. Akcan N, Poyrazoglu S, Bas F, Bundak R, Darendeliler F. Klinefelter syndrome in childhood: Variability in clinical and molecular findings. J Clin Res Pediatr Endocrinol. 2018;10(2):100–7. doi: 10.4274/jcrpe.5121. - DOI - PMC - PubMed
    1. Kang BS, Cho DK, Koh WJ, Yoo SH, Won KB, Cho YH, et al. A case of severe pulmonary thromboembolism in a young male with klinefelter syndrome. Korean Circ J. 2012;42(8):562–4. doi: 10.4070/kcj.2012.42.8.562. - DOI - PMC - PubMed
    1. van der Hulle T, Dronkers CE, Klok FA, Huisman MV. Recent developments in the diagnosis and treatment of pulmonary embolism. J Intern Med. 2016;279(1):16–29. doi: 10.1111/joim.12404. - DOI - PubMed

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