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. 2021 Oct;34(5):511-524.
doi: 10.37201/req/126.2021. Epub 2021 Oct 25.

Recommendations for antibiotic selection for severe nosocomial infections

J Mensa, J Barberán  1 , R Ferrer, M Borges, P Rascado, E Maseda, A Oliver, F Marco, R Adalia, G Aguilar, A Estella, R León López, M S Robles Marcos, F J González de Molina, R Serrano García, M Salavert, J Fernández Gómez, Y Poliakova, J Pasquau, J R Azanza, G Bou Arévalo, P LLinares Mondéjar, P Cardinal-Fernández, A Soriano
Affiliations

Recommendations for antibiotic selection for severe nosocomial infections

J Mensa et al. Rev Esp Quimioter. 2021 Oct.

Abstract
in English, Spanish

Severe infection and its evolution to sepsis are becoming more prevalent every day and are among the leading causes of critical illness and mortality. Proper management is crucial to improve prognosis. This document addresses three essential points that have a significant impact on this objective: a) early recognition of patients with sepsis criteria, b) identification of those patients who suffer from an infection and have a high risk of progressing to sepsis, and c) adequate selection and optimization of the initial antimicrobial treatment.

La infección grave y su evolución a sepsis son cada vez más frecuentes y se encuentran entre las principales causas de enfermedad crítica y mortalidad. El manejo adecuado es crucial para mejorar el pronóstico. Este documento desarrolla tres puntos esenciales que tienen un impacto significativo en este objetivo: a) el reconocimiento temprano de los pacientes que cumplen los criterios de sepsis, b) la identificación de aquellos pacientes que sufren una infección y tienen un alto riesgo de progresar a sepsis, y c) realizar una correcta elección y optimización del tratamiento antimicrobiano inicial.

Keywords: antimicrobial treatment; ceftazidime-avibactam; ceftolozane-tazobactam; meropenem; optimization; sepsis; septic shock; severe infection.

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Conflict of interest statement

RSG, JM, and RA have received honoraria for lectures and advisory boards from Pfizer. JP has received honoraria for lectures from Pfizer, MSD, Shionogi and Menarini and for advisory boards Pfizer, Shionogi, and Menarini. MS has received honoraria for lectures and advisory boards from Pfizer, MSD, Gilead, Angelini and Janssen. AE has received honoraria for lectures and advisory boards from Pfizer, Gilead, MSD and Shionogi. JP has received honoraria for lec tures from Pfizer, MSD, Angelini, Astellas, Advanz and Menarini. AS, has received honoraria for lectures and advisory boards from Pfizer, MSD, Angelini, Shionogi, Menarini and Gilead. Rest of authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Potentially serious infection, sepsis, and septic shock. Probability of survival.
Figure 2
Figure 2
Management of antibiotic treatment in patients with serious infection of nosocomial origin.
Figure 3
Figure 3
Antibiotic treatment guidelines for serious infection of nosocomial origin.
See this image and copyright information in PMC

References

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